2,4,6-tris(2-ethylaziridin-1-yl)-1,3,5-triazine, commonly known as ThioTEPA, is a potent alkylating agent that plays a significant role in chemotherapy for the treatment of various cancers. It functions by damaging the DNA in cancer cells, which inhibits their ability to reproduce and ultimately results in cell death.
18924-91-9
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Basic information
- Product Name: 2,4,6-tris(2-ethylaziridin-1-yl)-1,3,5-triazine
- Synonyms: 2,4,6-tris(2-ethylaziridin-1-yl)-1,3,5-triazine;2,4,6-Tris-(1-(2-ethylaziridinyl))-1,3,5-triazine;NRL-18B;TEAT;1,3,5-Triazine, 2,4,6-tris(2-ethyl-1-aziridinyl)-;Einecs 242-679-8;S-Triazine, 2,4,6-tris(2-ethyl-1-aziridinyl)-
- CAS NO:18924-91-9
- Molecular Formula: C15H24N6
- Molecular Weight: 288.39126
- EINECS: 242-679-8
- Product Categories: N/A
- Mol File: 18924-91-9.mol
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Chemical Properties
- Melting Point: N/A
- Boiling Point: 420.62°C (rough estimate)
- Flash Point: 227.1°C
- Appearance: /
- Density: 1.1128 (rough estimate)
- Vapor Pressure: 2.35E-08mmHg at 25°C
- Refractive Index: 1.6500 (estimate)
- Storage Temp.: N/A
- Solubility: N/A
- CAS DataBase Reference: 2,4,6-tris(2-ethylaziridin-1-yl)-1,3,5-triazine(CAS DataBase Reference)
- NIST Chemistry Reference: 2,4,6-tris(2-ethylaziridin-1-yl)-1,3,5-triazine(18924-91-9)
- EPA Substance Registry System: 2,4,6-tris(2-ethylaziridin-1-yl)-1,3,5-triazine(18924-91-9)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- WGK Germany:
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 18924-91-9(Hazardous Substances Data)
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18924-91-9 Usage
Uses
Used in Oncology:ThioTEPA is used as a chemotherapeutic agent for the treatment of various cancers, such as breast, ovarian, and bladder cancer. It is particularly effective in cases where other treatments have failed or when the cancer is advanced or recurring. The alkylating action of ThioTEPA damages the DNA in cancer cells, preventing their proliferation and leading to cell death.
Used in Advanced or Recurring Cancer Treatments:
ThioTEPA is used as a last resort for patients with advanced or recurring cancer that has not responded to other treatments. Its potent alkylating properties make it a valuable tool in the oncologist's arsenal for managing aggressive and treatment-resistant cancers.
However, it is important to note that ThioTEPA can also cause severe side effects, including bone marrow suppression and an increased risk of developing secondary cancers. Despite these risks, its effectiveness in treating certain types of cancer makes it an important component of cancer treatment strategies.
Check Digit Verification of cas no
The CAS Registry Mumber 18924-91-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,8,9,2 and 4 respectively; the second part has 2 digits, 9 and 1 respectively.Calculate Digit Verification of CAS Registry Number 18924-91:
(7*1)+(6*8)+(5*9)+(4*2)+(3*4)+(2*9)+(1*1)=139
139 % 10 = 9
So 18924-91-9 is a valid CAS Registry Number.
InChI:InChI=1/C15H24N6/c1-4-10-7-19(10)13-16-14(20-8-11(20)5-2)18-15(17-13)21-9-12(21)6-3/h10-12H,4-9H2,1-3H3
18924-91-9Upstream product
18924-91-9Downstream Products
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2,4,6-tris(2-ethylaziridin-1-yl)-1,3,5-triazine
