189254-14-6Relevant articles and documents
Indanyl piperazines as melatonergic MT2 selective agents
Mattson, Ronald J.,Catt, John D.,Keavy, Daniel,Sloan, Charles P.,Epperson, James,Gao, Qi,Hodges, Donald B.,Iben, Lawrence,Mahle, Cathy D.,Ryan, Elaine,Yocca, Frank D.
, p. 1199 - 1202 (2007/10/03)
Optimization of a benzyl piperazine pharmacophore produced N-acyl-4-indanyl-piperazines that bind with high affinity to melatonergic MT2 receptors. (R)-4-(2,3-dihydro-6-methoxy-1H-inden-1-yl)-N-ethyl-1-piperazine-carboxamide fumarate (13) is a water soluble, selective MT2 agonist, which produces advances in circadian phase in rats at doses of 1-56 mg/kg that are no different from those of melatonin at 1 mg/kg. Unlike melatonin, 13 produced only weak contractile effects in rat tail artery.