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AC-WEHD-AMC is a chemical compound utilized in biological research as a substrate for protease enzyme assays. It incorporates a fluorescent reporter molecule, AMC (7-amino-4-methylcoumarin), which is released upon protease cleavage, enabling the detection and quantification of protease activity in biological samples. The specific amino acid sequence WEHD in AC-WEHD-AMC serves as a known substrate for caspase-1, a protease enzyme that plays a role in inflammation and immunity. AC-WEHD-AMC is recognized for its sensitivity and specificity, making it a valuable tool in biochemical and pharmaceutical research for studying protease activity and developing therapeutic inhibitors.

189275-74-9

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189275-74-9 Usage

Uses

Used in Biochemical Research:
AC-WEHD-AMC is used as a substrate for protease enzyme assays to detect and quantify protease activity in biological samples. The release of the fluorescent reporter molecule AMC upon cleavage by proteases allows for the measurement of enzyme activity, which is crucial for understanding enzyme function and kinetics.
Used in Pharmaceutical Research:
In the pharmaceutical industry, AC-WEHD-AMC is used as a tool for developing and testing inhibitors targeting protease enzymes. Its specificity for caspase-1 makes it particularly useful in the study of inflammation and immunity, aiding in the development of drugs that modulate these processes.
Used in Inflammation and Immunity Research:
AC-WEHD-AMC is used as a substrate to study the activity of caspase-1, a key enzyme in the inflammatory response and immune system regulation. By monitoring the release of AMC, researchers can gain insights into the role of caspase-1 in these biological processes and identify potential therapeutic targets for inflammatory and immune-related disorders.

Check Digit Verification of cas no

The CAS Registry Mumber 189275-74-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,8,9,2,7 and 5 respectively; the second part has 2 digits, 7 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 189275-74:
(8*1)+(7*8)+(6*9)+(5*2)+(4*7)+(3*5)+(2*7)+(1*4)=189
189 % 10 = 9
So 189275-74-9 is a valid CAS Registry Number.

189275-74-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name AC-WEHD-AMC

1.2 Other means of identification

Product number -
Other names PASE-1 SUBSTRATE X,FLUOROGENIC

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:189275-74-9 SDS

189275-74-9Upstream product

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