189278-27-1

Basic information

• Product Name: 2-Bromo-6-(trifluoromethyl)pyridine
• Synonyms: 2-TRIFLUOROMETHYL-6-BROMOPYRIDINE;2-BROMO-6-(TRIFLUOROMETHYL)PYRIDINE;2-Bromo-6-(trifuluoromethyl)pyridine;6-BROMO-2-(TRIFLUOROMETHYL)PYRIDINE;2-bromo-6-trifluromethylpyridine;2-Bromo-6-(Trifuoromethyl )pyridine;6-Bromo-alpha,alpha,alpha-trifluoro-2-picoline;2-BroMo-6-(trifluoroMethyl)pyridine, 97+%
• CAS NO: 189278-27-1
• Molecular Formula: C₆H₃BrF₃N
• Molecular Weight: 225.99
• Product Categories: Halides;Pyridines;Pyridine;C6Heterocyclic Building Blocks;Halogenated Heterocycles;Heterocyclic Building Blocks;Fluorine series
• Mol File: 189278-27-1.mol
• Article Data: 1

Chemical Properties

• Melting Point: 48-52 °C
• Boiling Point: 78-79°C 14mm
• Flash Point: 78-79°C/14mm
• Appearance: beige moist crystals
• Density: 1.707 g/cm³
• Vapor Pressure: 1.93mmHg at 25°C
• Refractive Index: 1.471
• Storage Temp.: Room temperature.
• Solubility: soluble in Methanol
• PKA: -3.89±0.12(Predicted)
• CAS DataBase Reference: 2-Bromo-6-(trifluoromethyl)pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Bromo-6-(trifluoromethyl)pyridine(189278-27-1)
• EPA Substance Registry System: 2-Bromo-6-(trifluoromethyl)pyridine(189278-27-1)

Safety Data

• Hazard Codes: T,Xi,Xn
• Statements: 25-36/37/38-20/21/22
• Safety Statements: 26-37/39-45-36/37/39-22
• RIDADR: UN 2811 6.1/PG 3
• WGK Germany: 3
• HazardClass: IRRITANT
• PackingGroup: Ⅲ
• Hazardous Substances Data: 189278-27-1(Hazardous Substances Data)

Usage

Chemical Properties

White solid

InChI:InChI=1/C6H3BrF3N/c7-5-3-1-2-4(11-5)6(8,9)10/h1-3H

Upstream product

• 81290-20-2 (trifluoromethyl)trimethylsilane 
• 234111-08-1 2-iodo-6-bromopyridine 

Downstream Products

• 131747-42-7 6-(trifluoromethyl)pyridine-2-carboxylic acid 
• 335267-11-3 6-(trifluoromethyl)-1',2',3',6'-tetrahydro-2,4'-bipyridine 
• 1351143-65-1 (3aS,4S,6aS)-N-(3-fluorophenyl)-2-[6-(trifluoromethyl)pyridin-2-yl]octahydrocyclopenta[c]pyrrole-4-carboxamide 
• 1351142-63-6 N-{(3aR,4R,6aS)-4-methyl-2-[6-(trifluoromethyl)pyridin-2-yl]octahydrocyclopenta[c]pyrrol-4-yl}benzamide 
• 131747-53-0 [6-(trifluoromethyl)pyridin-2-yl]methanol 
• 749875-07-8 2-bromo-6-(trifluoromethyl)-3-pyridinecarboxylic acid 

Relevant articles and documents

Trifluoromethyl-substituted pyridines through displacement of iodine by in situ generated (trifluoromethyl)copper

A literature method reported for iodobenzene and congeners was successfully extended to the pyridine series. 2-Iodopyridines can be converted into 2-(trifluoromethyl)pyridines almost quantitatively. In contrast, yields are moderate at best if 3- and 4-iodopyridines or 2-bromopyridines are used as the starting materials. WILEY-VCH Verlag GmbH 2002.