189280-44-2

Basic information

• Product Name: [(2S,3R)-2-((R)-2-Benzyloxycarbonylamino-3-benzyloxycarbonylsulfanyl-propionylamino)-3-tert-butoxy-butyrylamino]-acetic acid carbamoylmethyl ester
• CAS NO: 189280-44-2
• Molecular Weight: 660.745
• Mol File: 189280-44-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: [(2S,3R)-2-((R)-2-Benzyloxycarbonylamino-3-benzyloxycarbonylsulfanyl-propionylamino)-3-tert-butoxy-butyrylamino]-acetic acid carbamoylmethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: [(2S,3R)-2-((R)-2-Benzyloxycarbonylamino-3-benzyloxycarbonylsulfanyl-propionylamino)-3-tert-butoxy-butyrylamino]-acetic acid carbamoylmethyl ester(189280-44-2)
• EPA Substance Registry System: [(2S,3R)-2-((R)-2-Benzyloxycarbonylamino-3-benzyloxycarbonylsulfanyl-propionylamino)-3-tert-butoxy-butyrylamino]-acetic acid carbamoylmethyl ester(189280-44-2)

Safety Data

• Hazardous Substances Data: 189280-44-2(Hazardous Substances Data)

Upstream product

• 71989-35-0 Fmoc-Thr(tBu)-OH 
• 57912-35-3 N,S-dicarbobenzoxy-L-cysteine 
• 189280-40-8 [(2S,3R)-3-tert-Butoxy-2-(9H-fluoren-9-ylmethoxycarbonylamino)-butyrylamino]-acetic acid carbamoylmethyl ester 

Downstream Products

• 189280-47-5 [(2S,3R)-2-((R)-2-Benzyloxycarbonylamino-3-benzyloxycarbonylsulfanyl-propionylamino)-3-tert-butoxy-butyrylamino]-acetic acid 

Relevant articles and documents

Development of a Hypusine Reagent for Peptide Synthesis

The synthesis of a reagent that enables the incorporation of the unusual amino acid (2S,9R)-hypusine (Hpu) into peptide sequences is described.The reagent, (2S,9R)-11--7-(carbobenzyloxy)-2--9-(tetrahydropyran-2-yloxy)-7-azaundecanoic acid, is utilized in the synthesis of a hexapeptide containing the primary pentapeptide sequence of the eukaryotic initiation factor eIF-5A, L-Cys-L-Thr-Gly-Hpu-L-His-Gly.The reagent is shown to be effective for both solution phase and Merrifield resin synthesis.