189281-48-9

Basic information

• Product Name: 2,4-Dichloro-5-fluoropyridine
• Synonyms: 2,4-Dichloro-5-fluoropyridine;Pyridine, 2,4-dichloro-5-fluoro-
• CAS NO: 189281-48-9
• Molecular Formula: C₅H₂Cl₂FN
• Molecular Weight: 165.98
• Mol File: 189281-48-9.mol

Chemical Properties

• Boiling Point: 183.8±35.0 °C(Predicted)
• Appearance: /
• Density: 1.498
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -1.13±0.10(Predicted)
• CAS DataBase Reference: 2,4-Dichloro-5-fluoropyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-Dichloro-5-fluoropyridine(189281-48-9)
• EPA Substance Registry System: 2,4-Dichloro-5-fluoropyridine(189281-48-9)

Safety Data

• Hazardous Substances Data: 189281-48-9(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2,4-Dichloro-5-fluoropyridine is used as a key intermediate in the synthesis of various pharmaceuticals for its ability to be transformed into a wide array of functionalized pyridine derivatives, contributing to the development of new drugs and treatments.
Used in Agrochemical Industry:
In the agrochemical sector, 2,4-Dichloro-5-fluoropyridine serves as an essential building block, facilitating the creation of novel compounds with potential applications in pest and disease control, thereby enhancing crop protection strategies.
Used in Organic Chemistry Research:
As a versatile compound in organic chemistry, 2,4-Dichloro-5-fluoropyridine is utilized in research for its capacity to undergo multiple chemical reactions, leading to the production of diverse pyridine-based compounds with potential applications across various fields.

Upstream product

• 51-21-8 5-fluorouracil 

Downstream Products

• 1350327-42-2 C₁₉H₁₆FN₃O₃ 
• 1364677-55-3 6-chloro-2-(4-chloro-phenyl)-3-(2,2,2-trifluoro-ethoxy)-pyridine 
• 1382465-66-8 2-(4-chloro-phenyl)-3-fluoro-6-(2,2,2-trifluoro-ethoxy)-pyridine 
• 874822-35-2 {4-[(2-chloro-5-fluoro-pyrimidin-4-ylamino)-methyl]-cyclohexyl}-carbamic acid tert-butyl ester 
• 1364677-59-7 6-(4-chlorophenyl)-5-(2,2,2-trifluoroethoxy)-2-pyridinecarboxylic acid 
• 1364677-57-5 6-(4-chloro-phenyl)-5-(2,2,2-trifluoro-ethoxy)-pyridine-2-carboxylic acid methyl ester 
• 1233697-21-6 6-chloro-2-(4-chloro-phenyl)-3-fluoro-pyridine 

Relevant articles and documents

Pyrimidine derivatives useful as inhibitors of PKC-theta

Disclosed are novel compounds of formula (I): wherein X, Y, R1, R2 and R3 are as defined herein, which are useful as inhibitors of PKC-theta and are thus useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of PKC-theta, including immunological disorders and type II diabetes. This invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.