189298-48-4

Basic information

• Product Name: (R)-Meclizine
• Synonyms: (R)-Meclizine;Piperazine, 1-[(4-chlorophenyl)phenylmethyl]-4-[(3-methylphenyl)methyl]-, (R)-;Piperazine, 1-[(R)-(4-chlorophenyl)phenylmethyl]-4-[(3-methylphenyl)methyl]- (9CI)
• CAS NO: 189298-48-4
• Molecular Formula: C25H27 Cl N2
• Molecular Weight: 0
• Mol File: 189298-48-4.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (R)-Meclizine(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-Meclizine(189298-48-4)
• EPA Substance Registry System: (R)-Meclizine(189298-48-4)

Safety Data

• Hazardous Substances Data: 189298-48-4(Hazardous Substances Data)

Usage

General Description

(R)-Meclizine is a chemical compound that is commonly used as an antihistamine and antiemetic medication. It is used to treat symptoms of motion sickness, vertigo, and dizziness. (R)-Meclizine works by blocking the action of histamine in the body, which helps to reduce symptoms such as nausea, vomiting, and dizziness. It is a stereoisomer of meclizine, and the (R)-enantiomer is known to have greater potency and longer duration of action compared to the (S)-enantiomer. (R)-Meclizine is available in various forms, including tablets, chewable tablets, and oral disintegrating tablets, and is generally well-tolerated with minimal side effects when used as directed.

Upstream product

• 303-26-4 N-(4-chlorobenzhydryl)piperazine 
• 620-23-5 m-tolyl aldehyde 
• 1104-22-9 Meclizine dihydrochloride 
• 5321-48-2 1-(3-methylbenzyl)piperazine 
• 104-88-1 4-chlorobenzaldehyde 

Relevant articles and documents

Bisulfite Addition Compounds as Substrates for Reductive Aminations in Water

Highly valued products resulting from reductive aminations utilizing shelf-stable bisulfite addition compounds of aldehydes can be made under aqueous micellar catalysis conditions. Readily available α-picolineborane serves as the stoichiometric hydride source. Recycling of the aqueous reaction medium is easily accomplished, and several applications to targets in the pharmaceutical industry are documented.

BF3·Et2O as a metal-free catalyst for direct reductive amination of aldehydes with amines using formic acid as a reductant

A versatile metal- and base-free direct reductive amination of aldehydes with amines using formic acid as a reductant under the catalysis of inexpensive BF3·Et2O has been developed. A wide range of primary and secondary amines and diversely substituted aldehydes are compatible with this transformation, allowing facile access to various secondary and tertiary amines in high yields with wide functional group tolerance. Moreover, the method is convenient for the late-stage functionalization of bioactive compounds and preparation of commercialized drug molecules and biologically relevant N-heterocycles. The procedure has the advantages of simple operation and workup and easy scale-up, and does not require dry conditions, an inert atmosphere or a water scavenger. Mechanistic studies reveal the involvement of imine activation by BF3and hydride transfer from formic acid.

DEUTERATED MECLIZINE

This invention relates to deuterated forms of meclizine, and pharmaceutically acceptable salts or hydrates thereof. This invention also provides compositions comprising a compound of this invention and the use of such compositions in methods of treating d