189339-99-9

Upstream product

• 2150-44-9 1-carbomethoxy-3,5-dihydroxybenzene 
• 2905-23-9 2-chlorophenylsulfonyl chloride 

Downstream Products

• 189340-02-1 2-Chlorobenzenesulfonic acid 3-[[1-N-(tert-butoxycarbonyl)piperidin-4-yl]methoxy]-5-carbomethoxyphenyl ester 
• 189341-30-8 2-chloro-benzenesulfonic acid 3-hydroxymethyl-5-(piperidin-4-ylmethoxy)-phenyl ester 
• 189341-28-4 4-[3-(2-chloro-benzenesulfonyloxy)-5-hydroxymethyl-phenoxymethyl]-piperidine-1-carboxylic acid tert-butyl ester 

Relevant academic research and scientific papers

Structure-activity and crystallographic analysis of a new class of non- amide-based thrombin inhibitor

The structure-activity relationships of a novel series of non-amide- based thrombin inhibitors are described. Exploration of the P2 and the aryl binding region for this series has identified optimal groups for achieving nanomolar potency. The binding modes of these optimal groups have been confirmed by X-ray structural analysis.

GUANIDINO PROTEASE INHIBITORS

Compounds of the formula: STR1 wherein R 1--R 4, R. sup.7--R 8, R a, R b, R c, Y, Z, n and m are set forth in the specification, as well as hydrates, solvates or pharmaceutically acceptable salts thereof, that inhibit a number of proteolytic enzymes are described. Also described are methods for preparing the compounds of Formula I.