189340-84-9Relevant academic research and scientific papers
Amidino derivatives and their use as thrombin inhibitors
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, (2008/06/13)
There is provided compounds of formula I, wherein R1, R2, R3, Y, n and B have meanings given in the description which are useful as competitive inhibitors of trypsin-like proteases, such as thrombin, and in particular in the treatment of conditions where inhibition of thrombin is required (e.g. thrombosis) or as anticoagulants.
Structure-activity and crystallographic analysis of a new class of non- amide-based thrombin inhibitor
Lu, Tianbao,Soll, Richard M.,Illig, Carl R.,Bone, Roger,Murphy, Larry,Spurlino, John,Salemme, F. Raymond,Tomczuk, Bruce E.
, p. 79 - 82 (2007/10/03)
The structure-activity relationships of a novel series of non-amide- based thrombin inhibitors are described. Exploration of the P2 and the aryl binding region for this series has identified optimal groups for achieving nanomolar potency. The binding modes of these optimal groups have been confirmed by X-ray structural analysis.
