189341-21-7Relevant articles and documents
AMIDINOHYDRAZONES AS PROTEASE INHIBITORS
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Page/Page column 25, (2010/11/23)
Amidino and benzamidino compounds, including compounds of the formula: I wherein R1-R4, R6-R9, Y, Z, n and m are set forth in the specification, as well as hydrates, solvates or pharmaceutically acceptable salts thereof, that inhibit proteolytic enzymes such as thrombin are described. Also described are methods for preparing the compounds of Formula I.
Amidino protease inhibitors
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, (2008/06/13)
Amidino and benzamidino compounds, including compounds of the formula: wherein R1-R4, R6-R9, Y, Z, n and m are set forth in the specification, as well as hydrates, solvates or pharmaceutically acceptable salts thereof, that inhibit a number of proteolytic enzymes are described. Also described are methods for preparing the compounds of Formula I.
Structure-activity and crystallographic analysis of a new class of non- amide-based thrombin inhibitor
Lu, Tianbao,Soll, Richard M.,Illig, Carl R.,Bone, Roger,Murphy, Larry,Spurlino, John,Salemme, F. Raymond,Tomczuk, Bruce E.
, p. 79 - 82 (2007/10/03)
The structure-activity relationships of a novel series of non-amide- based thrombin inhibitors are described. Exploration of the P2 and the aryl binding region for this series has identified optimal groups for achieving nanomolar potency. The binding modes of these optimal groups have been confirmed by X-ray structural analysis.
