189345-52-6

Basic information

• Product Name: 7 β - aMino - 3 - [4 - pyridyl - 2 - thiazole sulfur radical ] - 3 - cepheM - 4 - carboxylic acid
• Synonyms: 7 β - aMino - 3 - [4 - pyridyl - 2 - thiazole sulfur radical ] - 3 - cepheM - 4 - carboxylic acid
• CAS NO: 189345-52-6
• Molecular Formula: C16H14N4O3S3
• Molecular Weight: 406.50236
• Mol File: 189345-52-6.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 7 β - aMino - 3 - [4 - pyridyl - 2 - thiazole sulfur radical ] - 3 - cepheM - 4 - carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 7 β - aMino - 3 - [4 - pyridyl - 2 - thiazole sulfur radical ] - 3 - cepheM - 4 - carboxylic acid(189345-52-6)
• EPA Substance Registry System: 7 β - aMino - 3 - [4 - pyridyl - 2 - thiazole sulfur radical ] - 3 - cepheM - 4 - carboxylic acid(189345-52-6)

Safety Data

• Hazardous Substances Data: 189345-52-6(Hazardous Substances Data)

Usage

General Description

The chemical "7 β - aMino - 3 - [4 - pyridyl - 2 - thiazole sulfur radical ] - 3 - cepheM - 4 - carboxylic acid" is a cephalosporin antibiotic that contains a sulfur radical in its molecular structure. It has a beta-amino group and a carboxylic acid functional group. This chemical is commonly used in the medical field to treat bacterial infections. As a cephalosporin, it works by inhibiting the growth of bacteria and is effective against a wide range of bacterial strains. Its specific structure and mechanism of action make it an important tool in the fight against bacterial infections.

Upstream product

• 400827-68-1 4-(2-{[(6R,7R)-2-[(diphenylmethoxy)carbonyl]-8-oxo-7-(2-phenylacetamido)-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]sulfanyl}-1,3-thiazol-4-yl)pyridine 
• 63821-56-7 (6R,7R)-benzhydryl 3-chloro-8-oxo-7-(2-phenylacetamido)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate 
• 54639-48-4 (6R,7R)-benzhydryl 3-hydroxy-8-oxo-7-(2-phenylacetamido)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate 
• 189345-50-4 p-methoxybenzyl 7β-phenylacetamido-3-[4-(4-pyridyl)-1,3-thiazol-2-yl]thio-3-cephem-4-carboxylate 
• 77168-63-9 [4-(4-pyridyl)-1,3-thiazol-2-yl]thiol 
• 123054-30-8 (7R)-7-[(phenylacetyl)amino]-3-trifluoromethanesulfonyloxy-3-cephem-4-carboxylate, 4-methoxybenzyl ester 

Downstream Products

• 189345-04-8 ceftaroline 

Relevant articles and documents

A method for preparing cephalosporin lorraine ester

The invention relates to a synthetic method for ceftaroline fosamil. According to the synthetic method, 7-phenylacetamide-3-hydroxy-3-cephalosporin-4-carboxylate-diphenylmethyl is selected as a raw material to be chloridized and reacts with 4-(4-pyridyl)-1,3-thiazole-2-thiol sodium salt at a C-3 site to obtain a thioether compound, p-cresol and immobilized penicillinase are adopted for removing carboxyl and amino protecting groups respectively, the thioether compound and the acylated AE-active ester are subjected to C-7 site condensation reaction, and crystallization in acetic acid is performed after hydrolyzation to prepare the ceftaroline fosamil successfully. The preparation method has the advantages that use of toxic and harmful substances such as trifluoroacetic acid and phosphorus pentachloride is avoided, reaction conditions are moderate, side reactions are few, technology is simple, yield and product purity are high, cost is low, raw materials are cheap and easy to obtain, and the preparation method is applicable to industrial production.