189362-43-4

Basic information

• Product Name: (1R,2R)-2-CYCLOPROPYLAMINO CYCLOHEXANOL
• Synonyms: (1R,2R)-2-CYCLOPROPYLAMINO CYCLOHEXANOL;R-CPCH
• CAS NO: 189362-43-4
• Molecular Formula: C₉H₁₇NO
• Molecular Weight: 155.24
• Mol File: 189362-43-4.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 261.8±33.0 °C(Predicted)
• Appearance: /
• Density: 1.05±0.1 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 14.99±0.40(Predicted)
• CAS DataBase Reference: (1R,2R)-2-CYCLOPROPYLAMINO CYCLOHEXANOL(CAS DataBase Reference)
• NIST Chemistry Reference: (1R,2R)-2-CYCLOPROPYLAMINO CYCLOHEXANOL(189362-43-4)
• EPA Substance Registry System: (1R,2R)-2-CYCLOPROPYLAMINO CYCLOHEXANOL(189362-43-4)

Safety Data

• Hazardous Substances Data: 189362-43-4(Hazardous Substances Data)

Usage

General Description

(1R,2R)-2-Cyclopropylamino cyclohexanol, also known as rotigotine, is a chemical compound used in the treatment of Parkinson's disease and restless legs syndrome. It belongs to the class of non-ergoline dopamine agonists, which means it works by mimicking the effects of dopamine, a neurotransmitter that is deficient in Parkinson's disease. By binding to dopamine receptors in the brain, rotigotine helps to alleviate the motor symptoms of Parkinson's disease, such as tremors and stiffness. It is typically administered as a transdermal patch, providing a continuous release of the medication over a 24-hour period. Rotigotine has been shown to be effective in improving motor symptoms and quality of life in patients with Parkinson's disease, making it a valuable treatment option for this condition.

Upstream product

• 286-20-4 cyclohexene oxide 
• 765-30-0 Cyclopropylamine 
• 286-20-4 cyclohexane-1,2-epoxide 
• 189362-41-2 (S)-Hydroxy-phenyl-acetic acid (1R,2R)-2-cyclopropylamino-cyclohexyl ester 

Relevant articles and documents

Asymmetric amination of meso-epoxide with vegetable powder as a low-toxicity catalyst

This paper describes the scope and limitation of substrates subjected to asymmetric amination with epoxides catalyzed by a soluble soybean polysaccharide (Soyafibe S-DN), which we recently discovered from the reaction of 1,2-epoxycyclohexane with cyclopropylamine. Various meso-epoxides reacted with various amines afforded the corresponding products with good enantiomeric selectivity. Since it was found that pectin was found to have a catalytic ability after screening commercially available polysaccharides, we studied 33 different vegetable powders having pectic substances, and we found that many vegetable powders showed catalytic ability. These results should guide in using vegetable components as low-toxic catalysts for the production of pharmaceuticals.

2(1H)-Quinolinone derivatives as novel anti-arteriostenotic agents showing anti-thrombotic and anti-hyperplastic activities

In order to search for anti-arteriostenotic agents, a series of 2(1H)- quinolinone derivatives was synthesized and evaluated for anti-thrombotic activity and for anti-hyperplastic activity. From this series, (-)-6-[3-[3- cyclopropyl-3-[(1R,2R)-2-hydroxycycyclohexyl]ureido]propoxy]-2(1H)- quinolinone (1p, OPC-33509) was selected as the best candidate by balancing the efficacy on anti-thrombosis and anti-hyperplasia.