189385-64-6

Basic information

• Product Name: 2-Piperidinecarboxylicacid,4-hydroxy-,(2R,4R)-(9CI)
• Synonyms: 2-Piperidinecarboxylicacid,4-hydroxy-,(2R,4R)-(9CI);(2R,4R)-4-hydroxypiperidine-2-carboxylic acid
• CAS NO: 189385-64-6
• Molecular Formula: C6H11NO3
• Molecular Weight: 145.16
• Product Categories: CARBOXYLICACID
• Mol File: 189385-64-6.mol
• Article Data: 35

Chemical Properties

• Melting Point: 255-275 °C (decomp)
• Boiling Point: 346.0±42.0 °C(Predicted)
• Appearance: /
• Density: 1.299±0.06 g/cm3(Predicted)
• PKA: 2.28±0.40(Predicted)
• CAS DataBase Reference: 2-Piperidinecarboxylicacid,4-hydroxy-,(2R,4R)-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Piperidinecarboxylicacid,4-hydroxy-,(2R,4R)-(9CI)(189385-64-6)
• EPA Substance Registry System: 2-Piperidinecarboxylicacid,4-hydroxy-,(2R,4R)-(9CI)(189385-64-6)

Safety Data

• Hazardous Substances Data: 189385-64-6(Hazardous Substances Data)

Upstream product

• 653589-35-6 di(tert-butyl) (2S,4R)-4-hydroxy-1,2-piperidinedicarboxylate 
• 50299-14-4 N-Acetyl-α-allylglycine 
• 78553-51-2 (S)-2-(benzyloxycarbonylamino)pent-4-enoic acid 
• 78553-47-6 methyl (2S)-2-[N-(benzyloxycarbonyl)amino]pent-4-enoate 
• 653589-10-7 1,2-di-tert-butyl (2S)-4,6-dioxopiperidine-1,2-dicarboxylate 
• 244633-66-7 2-azido-6,7-O-cyclohexylidene-2,3,5-trideoxy-D-arabino-heptono-1,4-lactone 
• 244793-58-6 2-(N-benzyloxycarbonyl)amino-6-O-methanesulfonyl-2,3,5-trideoxy-D-threo-hexono-1,4-lactone 
• 244633-67-8 2-(N-benzyloxycarbonyl)amino-2,3,5-trideoxy-D-arabino-heptono-1,4-lactone 
• 211058-80-9 methyl 4(R)-hydroxypiperidine-2(S)-carboxylate 
• 326477-50-3 (2R,4S)-(+)-4-Acetoxy-2-phenyl-1-trifluoroacetylpiperidine 
• 244633-58-7 2-azido-6,7-O-cyclohexylidene-2,3,5-trideoxy-D-xylo-heptono-1,4-lactone 
• 244793-55-3 2-(N-benzyloxycarbonyl)amino-6-O-methanesulfonyl-2,3,5-trideoxy-L-threo-hexono-1,4-lactone 
• 244633-63-4 2-(N-benzyloxycarbonyl)amino-2,3,5-trideoxy-D-xylo-heptono-1,4-lactone 
• 225656-38-2 1-(9-fluorenylmethyl) 2-methyl (2R,4S)-4-formyloxy-1,2-piperidinedicarboxylate 

Downstream Products

• 1844-40-2 (2S,4R)-4-hydroxypiperidine-2-carboxylic acid 
• 441044-11-7 (4R)-1-(tert-butoxycarbonyl)-4-hydroxypiperidine-2-carboxylic acid 
• 441044-14-0 phenylmethanaminium (2R,4R)-1-(tert-butoxycarbonyl)-4-hydroxypiperidine-2-carboxylate 
• 1212688-40-8 Boc-4-hydroxypipecolic acid 
• 441044-12-8 (2S,4S)-N-Boc-4-hydroxypiperidine-2-carboxylic acid 
• 441044-14-0 (2S,4S)-N-Boc-4-hydroxypiperidine-2-carboxylic acid benzylamine salt 
• 917099-02-6 (2S,4S)-1-[(9H-fluoren-9-ylmethoxy)carbonyl]-4-hydroxy-2-piperidinecarboxylic acid 
• 917099-02-6 (2S,4R)-1-[(9H-fluoren-9-ylmethoxy)carbonyl]-4-hydroxy-2-piperidinecarboxylic acid 
• 98593-76-1 (+)-1-Acetyl-4-hydroxy-D-pipecolinsaeurelacton 
• 98593-76-1 4-Hydroxypipecolinsaeurelactonacetat 

Relevant articles and documents

CERAMIDE GALACTOSYLTRANSFERASE INHIBITORS FOR THE TREATMENT OF DISEASE

Described herein are compounds, methods of making such compounds, pharmaceutical compositions and medicaments containing such compounds, and methods of using such compounds to treat or prevent diseases or disorders associated with the enzyme ceramide galactosyltransferase (CGT), such as, for example, lysosomal storage diseases. Examples of lysosomal storage diseases include, for example, Krabbe disease and Metachromatic Leukodystrophy.

Improved Total Synthesis of Tubulysins and Design, Synthesis, and Biological Evaluation of New Tubulysins with Highly Potent Cytotoxicities against Cancer Cells as Potential Payloads for Antibody-Drug Conjugates

Improved, streamlined total syntheses of natural tubulysins such as V (Tb45) and U (Tb46) and pretubulysin D (PTb-D43), and their application to the synthesis of designed tubulysin analogues (Tb44, PTb-D42, PTb-D47-PTb-D49, and Tb50-Tb120), are described.

AN ENANTIOSELECTIVE PROCESS FOR THE SYNTHESIS OF (2S,4R)-4-HYDROXYPIPECOLIC ACID

The present invention relates to an improved process for synthesis of 4-hydroxy pipecolic acid. The present invention relates to an improved enantioselective process for the synthesis of (2S,4R)-4-hydroxypipecolic acid via Co(III) (salen)-catalyzed two stereocentered Hydrolytic Kinetic Resolution (HKR) of racemic 1,3-azido epoxide with good yields and high optical purity without any protecting groups. 10 31