18940-58-4

Usage

Uses

Used in Pharmaceutical Industry:
1,4-Diisobutyrylpiperazine is used as a reactant for the synthetic preparation of chloro enamines and bromo enamines, which are important intermediates in the synthesis of various pharmaceutical compounds. These enamines are key building blocks for the development of new drugs with potential applications in treating a wide range of medical conditions.
1,4-Diisobutyrylpiperazine is also used as a potential analgesic agent for the development of pain-relieving medications. Its investigation in this area highlights the compound's potential to contribute to the creation of new and effective pain management solutions.

InChI:InChI=1/C12H22N2O2/c1-9(2)11(15)13-5-7-14(8-6-13)12(16)10(3)4/h9-10H,5-8H2,1-4H3

Upstream product

• 110-85-0 piperazine 
• 79-30-1 isobutyryl chloride 
• 75-30-9 2-iodo-propane 
• 201230-82-2 carbon monoxide 

Relevant academic research and scientific papers

Metal catalyst-free by design. the synthesis of amides from alkyl iodides, carbon monoxide and amines by a hybrid radical/ionic reaction

Amides can be synthesized from alkyl iodides and amines in the presence of CO (20-25 atm), without using transition metal catalyst; the radical cascade is initiated thermally using AIBN and allyltributyltin.

A general and practical method of synthesis of 2-disubstituted-1- chloro- and 1-bromoenamines

Disubstituted-α-chloroenamines are useful synthetic intermediates which had earlier been prepared by the reaction of tertiary amides with phosgene. The toxicity of the latter led us to systematically investigate new synthetic routes towards α-chloro- and