189507-58-2Relevant academic research and scientific papers
Folate-based inhibitors of thymidylate synthase: Synthesis and antitumor activity of γ-linked sterically hindered dipeptide analogues of 2-desamino- 2-methyl-N10-propargyl-5,8-dideazafolic acid (ICI 198583)
Bavetsias, Vassilios,Jackman, Ann L.,Marriott, Jonathan H.,Kimbell, Rosemary,Gibson, William,Boyle, F. Thomas,Bisset, Graham M. F.
, p. 1495 - 1510 (2007/10/03)
In an effort to synthesize inhibitors of thymidylate synthase (TS) that do not undergo polyglutamation, a series of γ-linked sterically hindered dipeptide analogues of 2-desamino-2-methyl-N10-propargyl-5,8-dideazafolic acid (ICI 198583) was pre
