18956-16-6

Basic information

• Product Name: CARDAMONIN
• Synonyms: (E)-1-(2,4-DIHYDROXY-6-METHOXY-PHENYL)-3-PHENYL-PROPENONE;(E)-1-(2,4-Dihydroxy-6-methoxy-phenyl)-3-phenyl-;1-(2,4-Dihydroxy-6-Methoxyphenyl)-3-phenylprop-2-en-1-one;Cardamoni;1-(2,4-Dihydroxy-6-methoxyphenyl);-3-phenylprop-2-en-1-one
• CAS NO: 18956-16-6
• Molecular Formula: C₁₆H₁₄O₄
• Molecular Weight: 270.28
• Mol File: 18956-16-6.mol
• Article Data: 2

Chemical Properties

• Melting Point: 178 °C
• Boiling Point: 484.5oC at 760 mmHg
• Flash Point: 182.7oC
• Appearance: /
• Density: 1.282g/cm3
• Vapor Pressure: 5.2E-10mmHg at 25°C
• Refractive Index: 1.657
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 7.00±0.40(Predicted)
• CAS DataBase Reference: CARDAMONIN(CAS DataBase Reference)
• NIST Chemistry Reference: CARDAMONIN(18956-16-6)
• EPA Substance Registry System: CARDAMONIN(18956-16-6)

Safety Data

• Hazardous Substances Data: 18956-16-6(Hazardous Substances Data)

Usage

Uses

1-(2,4-dihydroxy-6-methoxyphenyl)-3-phenylprop-2-en-1-one is inhibits NO and PGE2 production and inhibits TXB2 production.

InChI:InChI=1/C16H14O4/c1-20-15-10-12(17)9-14(19)16(15)13(18)8-7-11-5-3-2-4-6-11/h2-10,17,19H,1H3/b8-7+

Upstream product

• 100-52-7 benzaldehyde 
• 84457-60-3 2'-hydroxy-4'-benzyloxy-6'methoxychalkone 
• 39548-89-5 1-(4-(benzyloxy)-2-hydroxy-6-methoxyphenyl)ethan-1-one 

Downstream Products

• 84457-61-4 Acetic acid 5-acetoxy-3-methoxy-2-(3-phenyl-propionyl)-phenyl ester 
• 76444-56-9 Uvangoletin 

Related news

CARDAMONIN (cas 18956-16-6) attenuates hyperalgesia and allodynia in a mouse model of chronic constriction injury-induced neuropathic pain: Possible involvement of the opioid system07/25/2019

Neuropathic pain arises from the injury of nervous system. The condition is extremely difficult to be treated due to the ineffectiveness and presence of various adverse effects of the currently available drugs. In the present study, we investigated the antiallodynic and antihyperlagesic properti...detailed

CARDAMONIN (cas 18956-16-6) inhibited cell viability and tumorigenesis partially through blockade of testes-specific protease 50-mediated nuclear factor-kappaB signaling pathway activation07/24/2019

Previous studies have shown that testes-specific protease 50 (TSP50), a pro-oncogene overexpressed in many types of tumors, could promote cell proliferation, invasion, tumorigenesis, and tumor metastasis, suggesting that it is a potential cancer therapeutic target in drug discovery. Here, a luci...detailed

Discovery of a highly active anticancer analogue of CARDAMONIN (cas 18956-16-6) that acts as an inducer of caspase-dependent apoptosis and modulator of the mTOR pathway07/23/2019

Cardamonin is a natural chalcone that has been shown to exhibit high anticancer activity. In an attempt to discover analogues of cardamonin with enhanced anticancer activity, 19 analogues were synthesized and tested against A549 and HK1 cell lines. Results of the MTS cell viability assay showed ...detailed

CARDAMONIN (cas 18956-16-6) from a medicinal herb protects against LPS-induced septic shock by suppressing NLRP3 inflammasome07/22/2019

Aberrant activation of NLRP3 inflammasome has been implicated in the pathogenesis of diverse inflammation-related diseases, and pharmacological molecules targeting NLRP3 inflammasome are of considerable value to identifying potential therapeutic interventions. Cardamonin (CDN), the major active ...detailed

Effect of CARDAMONIN (cas 18956-16-6) on hepatic ischemia reperfusion induced in rats: Role of nitric oxide07/20/2019

Ischemia reperfusion (I/R) injury is a cellular damage in a hypoxic organ following the restoration of oxygen delivery. It may occur during organ transplantation, trauma and hepatectomies. Nitric oxide (NO) effects during hepatic I/R are complicated. The iNOS-derived NO has a deleterious effect,...detailed

Protective effect of CARDAMONIN (cas 18956-16-6) against acetic acid-induced ulcerative colitis in rats07/19/2019

BackgroundUlcerative colitis (UC) is an inflammatory bowel disease with significant morbidity. Cardamonin is a natural chalcone derivative with considerable anti-inflammatory activity. Herein, the potential protective effect of cardamonin against UC was tested in a rat model.detailed

Autophagy induced by CARDAMONIN (cas 18956-16-6) is associated with mTORC1 inhibition in SKOV3 cells07/17/2019

BackgroundThe mammalian target of rapamycin (mTOR) integrates energy level to modulate cell proliferation and autophagy. Cardamonin exhibits anti-proliferative activity through inhibiting mTOR. In this study, the effect of cardamonin on autophagy and its mechanism on mTOR inhibition were investi...detailed

Relevant articles and documents

Syntheses of Two New Naturally Occurring Dihydrochalkones, Uvangolatin and 2',4'-Dihydroxy-4,6'-dimethoxydihydrochalkone

The structures proposed for the two naturally occurring dihydrochalkones, uvangolatin isolated from Uvaria angolensis as 2',4'-dihydroxy-6'-methoxydihydrochalkone (I) and another dihydrochalkone isolated from Iryanthera laevis as 2',4'-dihydroxy-4,6'-dime