18961-68-7

Basic information

• Product Name: 6-FLUORO-6-DEOXY-D-GALACTOPYRANOSE
• Synonyms: 6-FLUORO-6-DEOXY-D-GALACTOPYRANOSE;6-Fluoro-6-deoxy-D-galactopyranose97%;(3R,4S,5R,6S)-6-(Fluoromethyl)tetrahydro-2H-pyran-2,3,4,5-tetrol;6-Deoxy-6-fluoro-D-galactopyranose 97%;6-Deoxy-6-fluoro-D-galactopyranose97%
• CAS NO: 18961-68-7
• Molecular Formula: C₆H₁₁FO₅
• Molecular Weight: 182.15
• Mol File: 18961-68-7.mol
• Article Data: 10

Chemical Properties

• Melting Point: 161-162°C
• Boiling Point: 354.6°Cat760mmHg
• Flash Point: 164.2°C
• Appearance: /
• Density: 1.626g/cm³
• Vapor Pressure: 1.9E-06mmHg at 25°C
• Refractive Index: 1.554
• CAS DataBase Reference: 6-FLUORO-6-DEOXY-D-GALACTOPYRANOSE(CAS DataBase Reference)
• NIST Chemistry Reference: 6-FLUORO-6-DEOXY-D-GALACTOPYRANOSE(18961-68-7)
• EPA Substance Registry System: 6-FLUORO-6-DEOXY-D-GALACTOPYRANOSE(18961-68-7)

Safety Data

• Hazard Codes: Xi
• Statements: 20/21/22
• Safety Statements: 22-36/37/39
• HazardClass: IRRITANT, IRRITANT-HARMFUL
• Hazardous Substances Data: 18961-68-7(Hazardous Substances Data)

Usage

General Description

6-FLUORO-6-DEOXY-D-GALACTOPYRANOSE is a chemical compound with the molecular formula C6H11FO5. It is a fluorinated derivative of the sugar galactose, containing a fluorine atom in place of one of the hydroxyl groups. The compound has a six-membered ring structure and is classified as a pyranose sugar. This chemical is commonly used as a precursor for the synthesis of various pharmaceuticals and other organic compounds. Its unique fluorinated structure gives it special properties that make it valuable in the field of medicinal chemistry and drug development.

InChI:InChI=1/C6H11FO5/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-6,8-11H,1H2/t2-,3+,4+,5-,6?/m1/s1

Upstream product

• 2021-97-8 6-deoxy-6-fluoro-1,2:3,4-di-O-isopropylidene-α-D-galctopyranose 
• 4536-13-4 methyl 6-deoxy-6-fluoro-α-D-galactopyranoside 
• 70981-54-3 6-deoxy-6-fluoro-1,2:3,4-di-O-isopropylidene-α-L-galactopyranose 
• 4064-06-6 1,2:3,4-di-O-isopropylidene-α-L-galactopyranose 
• 70932-48-8 (3aS,5R,5aS,8aR,8bS)-2,2,7,7-tetramethyltetrahydro-5H-bis([1,3]dioxolo)[4,5-b:4',5'-d]pyran-5-carbaldehyde 
• 5463-33-2 D-galactose-diethyl-dithioacetal 
• 357611-31-5 2,3,4,5-tetra-O-trimethylsilyl-D-galacto-hexodialdose-1 diethyl dithioacetal 
• 357611-44-0 1,2:3,4-di-O-isopropylidene-6-O-(trifluoromethanesulfonyl)-α-L-galactopyranose 
• 357611-36-0 1,2:3,4-di-O-isopropylidene-L-galacto-hexodialdo-1,5-pyranose-6 diethyl dithioacetal 
• 4064-06-6 1,2:3,4-di-O-isopropylidene-α-D-galactopyranose 
• 10257-28-0 D-Galactose 
• 3396-99-4 methyl α-D-galactopyranoside 
• 357611-28-0 2,3,4,5,6-penta-O-trimethylsilyl-D-galactose diethyl dithioacetal 

Downstream Products

• 155488-15-6 1,2,3,4-tetra-O-acetyl-6-deoxy-6-fluoro-D-galactopyranose 
• 118396-37-5 1,2,3,4-tetra-O-acetyl-6-deoxy-6-fluoro-β-D-galactopyranose 
• 674782-58-2 1,2,3,4-tetra-O-acetyl-6-deoxy-6-fluoro-α-L-galactopyranose 
• 674782-58-2 1,2,3,4-tetra-O-acetyl-6-deoxy-6-fluoro-β-L-galactopyranose 
• 303069-75-2 dibenzylphosphoryl 2,3,4-tri-O-benzoyl-6-deoxy-6-fluoro-β-L-galactopyranoside 
• 303069-73-0 1,2,3,4-tetra-O-benzoyl-6-deoxy-6-fluoro-L-galactopyranoside 

Relevant articles and documents

Fluorinated Carbohydrates as Lectin Ligands: Simultaneous Screening of a Monosaccharide Library and Chemical Mapping by 19F NMR Spectroscopy

Molecular recognition of carbohydrates is a key step in essential biological processes. Carbohydrate receptors can distinguish monosaccharides even if they only differ in a single aspect of the orientation of the hydroxyl groups or harbor subtle chemical

Fluorinated glycosyl amino acids for mucin-like glycopeptide antigen analogues

The aberrant glycosylation profiles of mucin glycoproteins on epithelial tumour cells represent attractive target structures for the development of immunotherapy against cancer. Mucin-type glycopeptides have been successfully investigated as molecularly defined vaccine prototypes for triggering humoral immunity but are susceptible to rapid in vivo degradation. As a potential means to enhance the bioavailabilities of the antigenic structures, hydrolysis-resistant carbohydrate analogues with fluorine substituents at positions C6, C2′ and C6′ were synthesised and incorporated into the tandem repeat sequence of the mucin MUC1. The resulting pseudo-glycopeptides can be used to elucidate the effects of chemically modified antibody determinants on metabolic and immunological properties.

Chemo-enzymatic synthesis of fluorinated sugar nucleotide: Useful mechanistic Probes for glycosyltransferases

An effective procedure for the synthesis of 2-deoxy-2-fluoro-sugar nucleotides via Selectfluor-mediated electrophilic fluorination of glycals with concurrent nucleophilic addition or chemo-enzymatic transformation has been developed, and the fluorinated sugar nucleotides have been used as probes for glycosyltransferases, including fucosyltransferase III, V, VI, and VII, and sialyl transferases. In general, these fluorinated sugar nucleotides act as competitive inhibitors versus sugar nucleotide substrates and form a tight complex with the glycosyltransferase. Copyright (C) 2000 Elsevier Science Ltd.