189623-72-1

Upstream product

• 100-46-9 benzylamine 
• 189623-62-9 3,6-Dichloro-pyridazine-4-carboxylic acid (2-chloro-5-nitro-phenyl)-methyl-amide 
• 6283-25-6 H₂NC₆H₃(Cl)NO₂ 
• 189623-61-8 3,6-dichloro-N-(2-chloro-5-nitrophenyl)-pyridazine-4-carboxamide 
• 6531-08-4 3,6-dichloropyridazine-5-carboxylic acid chloride 

Downstream Products

• 189623-83-4 5-Benzyl-2-chloro-10-methyl-8-nitro-5,10-dihydro-3,4,5,10-tetraaza-dibenzo[a,d]cyclohepten-11-one 

Relevant academic research and scientific papers

Synthesis of pyridazino[3,4-b][1,5]benzodiazepin-5-ones and their biological evaluation as non-nucleoside HIV reverse transcriptase inhibitors

Starting from 3,6-dichloro-N-(2-chloro-5-nitrophenyl)-pyridazine-4-carboxamine (7) a series of 6,11-dialkylated pyridazino-[3,4-b][1,5]benzodiazepin-5-ones with a 3-chloro-8-nitro, 8-amino, 8-acetylamino, or 8-chloro substitution pattern was prepared via N-alkyl-3-alkylamino-6-chloro-N-(2-chloro-5-nitrophenyl)-pyridazine-4- carboxamides. The new compounds were screened as non-nucleoside reverse transcriptase inhibitors. The influence of the substitution pattern in compounds 10-13 on inhibitory potency is discussed.