18967-44-7

Usage

Uses

2-Chlorobenzyl isothiocyanate is used as pharmaceutical intermediate.

InChI:InChI=1/C8H6ClNS/c9-8-4-2-1-3-7(8)5-10-6-11/h1-4H,5H2

Upstream product

• 89-97-4 2-CHLOROBENZYLAMINE 
• 31088-85-4 (2-chloro-benzyl)-dithiocarbamic acid; triethylamine salt 

Downstream Products

• 19380-80-4 1-(2-chlorobenzyl)thiourea 
• 109810-56-2 N-(2-chloro-benzyl)-N'-[1]naphthyl-thiourea 
• 109810-59-5 1-(2-chloro-benzyl)-3-naphthalen-2-yl-thiourea 
• 132982-33-3 N-benzyl-N'-(2-chloro-benzyl)-thiourea 
• 31964-49-5 1,3-bis-(2-chloro-benzyl)-thiourea 
• 103861-95-6 1-(2-chloro-benzyl)-3-(4,5-dihydro-thiazol-2-yl)-thiourea 
• 51623-91-7 1-(2-chloro-benzyl)-3-thiazol-2-yl-thiourea 
• 46420-01-3 1-(o-Chloro-)-benzyl-3-amidino-thiourea 

Relevant academic research and scientific papers

Na2S2O8-mediated efficient synthesis of isothiocyanates from primary amines in water

We have developed two green, practical, and efficient procedures, including a one-pot one, to synthesize isothiocyanates from amines and carbon disulfide via desulfurization with sodium persulfate. Water is used as the solvent. Basic conditions are necessary for good chemoselectivity for isothiocyanates. Structurally diverse linear and branched alkyl amines and aryl amines are readily converted to isothiocyanates by the two procedures in satisfactory yields. Halogens, benzylic C-H bonds, methylthio, nitro, ester, alkenyl, electron-rich or -deficient (hetero)aryls, acetylenyl, and even phenolic and alcoholic hydroxyls are well tolerated. The one-pot procedure in water can also be used to realize the preparation of chiral isothiocyanates from chiral amines, and the modification of bioactive structures with free amino groups. In large-scale preparation, simple and practical purification procedures independent of column chromatography are developed.

Tricyclic Compounds As mPGES-1 Inhibitors

The present invention relates to tricyclic compounds of formula (I) or pharmaceutically acceptable salt thereof as mPGES-1 inhibitors. These compounds are inhibitors of the microsomal prostaglandin E synthase-1 (mPGES-1) enzyme and are therefore useful in the treatment of pain and/or inflammation from a variety of diseases or conditions, such as asthma, osteoarthritis, rheumatoid arthritis, acute or chronic pain and neurodegenerative diseases.