189683-86-1 Usage
Uses
Used in Pharmaceutical Industry:
(R)-3-METHOXYMETHOXY-4-METHYLMANDELONITRILE is used as a key intermediate in the synthesis of pharmaceuticals for its potential to contribute to the development of new drugs. Its unique stereochemistry and functional groups can be leveraged to create molecules with specific biological activities, making it valuable in drug discovery and medicinal chemistry.
Used in Organic Synthesis:
In the field of organic synthesis, (R)-3-METHOXYMETHOXY-4-METHYLMANDELONITRILE serves as a building block for creating a variety of organic compounds. Its reactivity and structural features allow chemists to use it in the assembly of complex molecules, which can be applied across different industries, including materials science, agrochemicals, and specialty chemicals.
Used in Research and Development:
(R)-3-METHOXYMETHOXY-4-METHYLMANDELONITRILE is utilized as a subject of research for understanding its chemical properties, reactivity, and potential applications. Its unique structure makes it an interesting compound for exploring new reaction pathways and developing innovative synthetic methods, contributing to the advancement of chemical science.
Check Digit Verification of cas no
The CAS Registry Mumber 189683-86-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,8,9,6,8 and 3 respectively; the second part has 2 digits, 8 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 189683-86:
(8*1)+(7*8)+(6*9)+(5*6)+(4*8)+(3*3)+(2*8)+(1*6)=211
211 % 10 = 1
So 189683-86-1 is a valid CAS Registry Number.
189683-86-1Relevant academic research and scientific papers
Synthesis of the Adrenergic Bronchodilators (R)-Terbutalinel and (R)-Salbutamol from (R)-Cyanohydrins
Effenberger, Franz,Jaeger, Juergen
, p. 3867 - 3873 (2007/10/03)
Stereoselective syntheses of (R)-terbutaline and (R)-salbutamol acetal, which are important bronchodilators, starting from O-protected (R)-cyanohydrins are described. (R)-Terbutaline hydrochloride (R)-9·HCl is obtained in an overall yield of 44% with >98% ee from the O-bisallyl-protected cyanohydrin (R)-4k via a Ritter N-tertiary butylation to the amide (R)-6a, hydrogenation to the amino alcohol (R)-7a, and deprotection of the hydroxyl functions. (R)-Salbutamol acetals (R)-7b,c can be obtained from the corresponding O-protected (R)-cyanohydrins either via the route described for (R)-terbutaline or via selective hydrogenation of the protected cyanohydrin (R)-11 to the imino derivative, transimination with tert-butylamine, followed by hydrogenation with NaBH4 to give the 2-amino alcohol derivative (R)-12. Desilylation of (A)-12 to (R)-7c is performed with LiAlH4. Hydrolytic cleavage of the acetals (A)-7b and c to (R)-salbutamol was not yet possible without racemization.
