189691-23-4

Upstream product

• 1373402-14-2 8,10-bis(allyloxy)-3,4-dihydroxy-2-(hydroxymethyl)-9-methoxy-2,3,4,4a-tetrahydropyrano[3,2-c]isochromen-6(10bH)-one 
• 1403502-97-5 C₂₇H₂₈O₁₁ 
• 477-90-7 bergenin 

Relevant academic research and scientific papers

Structure-activity relationships of bergenin derivatives effect on α-glucosidase inhibition

The α-glucosidase inhibitory activities of bergenin derivatives were evaluated. Bergenin derivatives were synthesized from bergenin which is a characteristic compound of B. ligulata. A new bergenin derivative, 11-O-(3',4'-dimethoxybenzoyl)-bergenin showed

Synthesis and biological evaluation of bergenin analogues as mushroom tyrosinase inhibitors

In this manuscript, we synthesized a series of bergenin analogues, analyzed their structural importance for two biologic activities (anitioxidant activity (ORAC) and mushroom tyrosinase inhibitory activity). Among them, compound 5 which contains catechol moiety exhibited the most antioxidant activity (3.75 μmol of Trolox equiv. per μmol of 5). Furthermore, compound 5 was found to be the most potent (IC50 value = 17.5 ± 0.04 μM) when compared with the standard tyrosinase inhibitors of arbutin (IC50 value = 221.8 ± 1.9 μM) and kojic acid (IC50 value = 46.6 ± 3.8 μM). The bergenin moiety, the ester linkage, and benzoic acid moiety of bergenin derivatives affected two biologic activities. Tyrosinase inhibitory activity was affected by substituents of benzoic acid moiety. This manuscript provides a good foundation for the design and development of new tyrosinase inhibitors.