18977-34-9Relevant academic research and scientific papers
Chemoselective Claisen-Schmidt bis-substitutional condensation catalyzed by an alkoxy-bridged dinuclear Ti(IV) cluster
Wu, Yufei,Hou, Jie,Liu, Yuliang,Zhang, Mingfu,Tung, Chen-Ho,Wang, Yifeng
, p. 1511 - 1516 (2016/03/01)
The highly efficient and chemoselective α,α′-bis-substitution of alkanones is important in organic synthesis. Herein, a dimeric titanium cluster, Ti2Cl2(OPri)6·2HOPri (Ti2), is used in the Claisen-Schmidt condensation reaction, for the selectively activation of symmetrical ketones containing α,α′-methylene groups and production of α,α′-bis-substituted alkanones in high efficiency and chemoselectivity. The high efficiency and chemoselectivity can be extended to a variety of typical alkanones and aromatic aldehydes. Both of the oxo-bridged dimeric motif of Ti2 and the ionic Ti-Cl bond are responsible for the high efficiency and chemoselectivity.
Synthesis, molecular modeling and bio-evaluation of cycloalkyl fused 2-aminopyrimidines as antitubercular and antidiabetic agents
Singh, Nimisha,Pandey, Sarvesh Kumar,Anand, Namrata,Dwivedi, Richa,Singh, Shyam,Sinha, Sudhir Kumar,Chaturvedi, Vinita,Jaiswal, Natasa,Srivastava, Arvind Kumar,Shah, Priyanka,Siddiqui, M. Imran,Tripathi, Rama Pati
scheme or table, p. 4404 - 4408 (2011/09/12)
An economical and efficient one step synthesis of a series of 8-(arylidene)-4-(aryl)-5,6,7,8-tetrahydro-quinazolin-2-ylamines and 9-(arylidene)-4-(aryl)-6,7,8,9-tetrahydro-5H-cycloheptapyrimidin-2-ylamines by the reaction of bis-benzylidene cycloalkanones and guanidine hydrochloride in presence of NaH has been developed. All the synthesized compounds were evaluated against Mycobacterium tuberculosis H37Rv strain and the α-glucosidase and glycogen phosphorylase enzymes. Few of the compounds have shown interesting in vitro activity with MIC up to 3.12 μg/mL against M. tuberculosis and very good inhibition of α-glucosidase and glycogen phosphorylase enzymes. The most potent non toxic compound 40 exhibited about 58% ex vivo activity at MIC of 3.12 μg/mL. The present study opens a new gate to synthesize antitubercular agents for diabetic TB patients. In silico docking studies indicate that mycobacterial dihydrofolate reductase is the possible target of these compounds.
New Aziridines and Pyrazolines Derived from Diarylidenecycloalkanones
Kabli, R. A.,Kaddah, A. M.,Khalil, A. M.,Khalaf, A. A.
, p. 152 - 156 (2007/10/02)
A number of diarylidenecycloalkanones (I and II) have been prepared by the condensation of cycloalkanones with different aromatic aldehydes.Treatment of I and II with bromine gives the corresponding tetrabromides (III and IV).Compounds III react with meth
