18980-00-2

Basic information

• Product Name: 2-chloro-4-ethylphenol
• Synonyms: 2-chloro-4-ethylphenol;Phenol, 2-chloro-4-ethyl-
• CAS NO: 18980-00-2
• Molecular Formula: C₈H₉ClO
• Molecular Weight: 156.60946
• EINECS: 242-717-3
• Mol File: 18980-00-2.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 223.4 °C at 760 mmHg
• Flash Point: 88.9 °C
• Appearance: white like or light brown crystalline powder
• Density: 1.18 g/cm³
• Vapor Pressure: 0.0395mmHg at 25°C
• Refractive Index: 1.555
• CAS DataBase Reference: 2-chloro-4-ethylphenol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-chloro-4-ethylphenol(18980-00-2)
• EPA Substance Registry System: 2-chloro-4-ethylphenol(18980-00-2)

Safety Data

• Hazardous Substances Data: 18980-00-2(Hazardous Substances Data)

Usage

InChI:InChI=1/C8H9ClO/c1-2-6-5-7(9)3-4-8(6)10/h3-5,10H,2H2,1H3

Upstream product

• 123-07-9 4-Ethylphenol 
• 7791-25-5 sulfuryl dichloride 
• 56-23-5 tetrachloromethane 
• 2892-29-7 3-chloro-4-hydroxy-acetophenone 

Downstream Products

• 90919-40-7 (4-ethyl-2-chloro-phenoxy)-acetic acid 
• 32862-28-5 C₁₆H₁₆ClNO₄ 
• 38946-49-5 2-Aminomethyl-6-chloro-4-ethyl-phenol; hydrochloride 

Relevant articles and documents

Selective hydrodeoxygenation of hydroxyacetophenones to ethyl-substituted phenol derivatives using a FeRu?SILP catalyst

The selective hydrodeoxygenation of hydroxyacetophenone derivatives is achieved opening a versatile pathway for the production of valuable substituted ethylphenols from readily available substrates. Bimetallic iron ruthenium nanoparticles immobilized on an imidazolium-based supported ionic liquid phase (Fe25Ru75?SILP) show high activity and stability for a broad range of substrates without acidic co-catalysts. This journal is

The Multiple Facets of Iodine(III) Compounds in an Unprecedented Catalytic Auto-amination for Chiral Amine Synthesis

Iodine(III) reagents are used in catalytic one-pot reactions, first as both oxidants and substrates, then as cross-coupling partners, to afford chiral polyfunctionalized amines. The strategy relies on an initial catalytic auto C(sp3)?H amination of the iodine(III) oxidant, which delivers an amine-derived iodine(I) product that is subsequently used in palladium-catalyzed cross-couplings to afford a variety of useful building blocks with high yields and excellent stereoselectivities. This study demonstrates the concept of self-amination of the hypervalent iodine reagents, which increases the value of the aryl moiety.

Kinetics of chlorination of phenol and monosubstituted phenols by t-butyl hypochlorite in aqueous alkaline medium

The kinetics of chlorination of the parent and sixteen monosubstituted phenols (2-chloro, 2-methyl, 2-carboxy, 2-nitro, 3-chloro, 3-methyl, 3-carboxy, 4-fluoro, 4-chloro, 4-bromo, 4-methyl, 4-ethyl, 4-methoxy, 4-carboxy, 4-acetyl and 4-nitro) by t-BuOCl have been studied in aqueous alkaline medium. The rates of reactions show first order kinetics each in |t-BuOCl| and |XC 6H4OH| and inverse first order in |OH-|. Variation in either ionic strength or addition of reaction product has no significant effect on the rates of reactions, while lowering of the dielectric constant of the medium increases the rate. The rates are measured at different temperatures and the activation parameters for all the phenols computed. A mechanism involving the electrophilic attack of phenoxide ions by HOCl in the rate determining step is suggested. The rates decrease in the order: 3-CH 3 > 2-CH3 > 4-OCH3 > 4-CH3 > 4-C2H5 > H > 3-Cl > 3-COO- > 4-F > 2-COO- > 4-Br > 2-Cl > 4-Cl > 4-COO- > 4-COCH3 > 2-NO2 > 4-NO2. Hammett equation of the type, log k = -3.44 - 2.35 ρ is found to be valid for substituent effects. The enthalpy and entropy of activation are correlated.