18984-16-2

Usage

Uses

Used in Pharmaceutical Industry:
3,4-Dichloro-omega-nitrostyrene is used as a key intermediate in the synthesis of various pharmaceuticals for its ability to participate in multiple types of chemical reactions, facilitating the creation of diverse medicinal compounds.
Used in Specialty Chemicals Production:
In the specialty chemicals industry, 3,4-dichloro-omega-nitrostyrene serves as a reactive building block, enabling the development of unique chemical entities with specific applications, such as in materials science or agrochemicals.
Used in Organic Synthesis:
3,4-Dichloro-omega-nitrostyrene is employed as a versatile reactant in organic synthesis, particularly for its capacity to undergo Michael reactions, which are essential for the preparation of complex organic molecules with potential applications in various fields.

InChI:InChI=1/C8H5Cl2NO2/c9-7-2-1-6(5-8(7)10)3-4-11(12)13/h1-5H/b4-3+

Upstream product

• 75-52-5 nitromethane 
• 6287-38-3 3,4-dichlorobenzaldehyde 

Downstream Products

• 92023-56-8 6-Nitro-5-<3,4-dichlorphenyl>-bicyclo<2.2.1>hepten-(2) 
• 91398-79-7 5-Nitro-4-<3.4-dichlor-phenyl>-cyclohexen 
• 1108735-19-8 diethyl 2-(1-(3,4-dichlorophenyl)-2-nitroethyl)malonate 
• 1228600-00-7 (1R,5R,6S,7R)-6-(3,4-dichlorophenyl)-1-hydroxy-7-nitrobicyclo[3.2.1]octan-8-one 
• 1294505-77-3 C₁₁H₁₁Cl₂NO₃ 
• 1296869-86-7 (3S,4S,5R,6R)-3-benzyl-4-(3,4-dichlorophenyl)-5-nitro-6-phenylcyclohex-1-enecarbaldehyde 
• 1296869-74-3 (2R,3S)-2-benzyl-3-(3,4-dichlorophenyl)-4-nitrobutan-1-ol 
• 1352953-46-8 C₁₇H₁₃Cl₂NO₄ 
• 1420742-99-9 1-(tert-butoxyformamido)-2,2-dibromo-1-(3,4-dichlorophenyl)-2-nitroethane 
• 1459775-51-9 3-(3,4-dichloro-phenyl)quinolin-2(1H)-one 
• 1555971-81-7 (3-(3,4-dichlorophenyl)-5-phenyl-1H-pyrrol-2-yl)(phenyl)methanone 
• 21581-45-3 2-(3,4-dichlorophenyl)ethanamine 
• 1621003-22-2 (3R,4R,5R)-3-(4-chlorophenyl)-5-(3,4-dichlorophenyl)-1,3-dimethyl-4-nitropyrazolidine 

Relevant academic research and scientific papers

Facile Synthesis of 1,3,5-Triarylbenzenes and 4-Aryl-NH-1,2,3-Triazoles Using Mesoporous Pd-MCM-41 as Reusable Catalyst

We report mesoporous nano-Pd-MCM-41 catalyzed rapid and efficient synthesis of 1,3,5-triarylbenzenes via de-nitrative cyclotrimerization of β-nitrostyrenes. All the reactions were very fast and high yielding. The Pd-MCM-41 was also very effective in catalyzing de-nitrative [3+2] cycloaddition of β-nitrostyrenes with TMSN3 to synthesize 4-aryl-NH-1,2,3-triazoles. The catalyst was reused at least up to eight times with minimum loss of catalytic activity.

Cinnamic acid derivative and preparation method and application thereof

The invention provides a cinnamic acid derivative. The cinnamic acid derivative is of the structure as shown in the formula I. The invention also provides two methods for preparing the cinnamic acid derivative. The two methods depend on a single bond or double bonds in the structure shown in the formula I. The invention further provides a pesticide. The pesticide comprises the cinnamic acid derivative. In addition, the invention provides a sterilization method. The sterilization method includes the step of applying the cinnamic acid derivative or the pesticide to crops. The crops include rice,wheat, fruit trees and vegetables. The low-toxicity, low-residue-content and high-activity environment-friendly cinnamic acid derivative is developed, and the cinnamic acid derivative pesticide can replace traditional high-toxicity and high-residue-content pesticides.

Squaramide-Linked Chloramphenicol Base Hybrid Catalysts for the Asymmetric Michael Addition of 2,3-Dihydrobenzofuran-2-carboxylates to Nitroolefins

An array of hybrid catalysts incorporating a chloramphenicol base moiety linked to another chiral scaffold through a squaramide linker were developed and successfully used in the Michael addition of 2,3-dihydrobenzofuran-2-carboxylates to nitroolefins. Control experiments suggested that the hybrid catalysts were more reactive than nonhybridized bifunctional catalysts, and matching of the chirality between the two scaffolds was crucial for high reactivity and stereoselectivity. These hybrid organocatalysts could be used with a variety of substrates. At a 0.5 mol-% catalyst loading, a range of 2,3-dihydrobenzofuran-2-carboxylates derivatives bearing quaternary and tertiary stereogenic centers were obtained in high yields (up to 98 %) with excellent enantioselectivities (up to 99 % ee) and moderate diastereoselectivities (up to 8:92 dr).

ZrCl4-mediated synthesis of 1,2,3-triazoles from vinyl nitrates and their biological evaluation

A ZrCl4-mediated simple method for the conversion of vinyl nitrates to 1,2,3-triazoles in excellent yields is developed. The obtained new triazoles were evaluated for their antimicrobial activity.

17a-HYDROXYLASE/C17,20-LYASE INHIBITORS

The present invention provides compounds of Formula (I), or a pharmaceutically acceptable salt thereof, where R1, R2, R3, R4, R5, R6, A and n are as defined herein. A deuteriated derivative of the compound of Formula (I) is also provided.

17α-HYDROXYLASE/C17,20-LYASE INHIBITORS

The present invention provides compounds of Formula (I), or a pharmaceutically acceptable salt thereof, where R1, R2, R3, R4, R5, R6, A and n are as defined herein. A deuteriated derivative of the compound of Formula (I) is also provided.