189875-85-2

Upstream product

• 5291-48-5 bis(4-methoxyphenyl)methanimine 
• 27532-96-3 glycine tert-butyl ester hydrochloride 

Downstream Products

• 1012085-21-0 1-tert-butyl 5-methyl 2-(bis(4-methoxyphenyl)methyleneamino)-3-methylpentanedioate 
• 1067981-10-5 2-tert-butyl 4-methyl 5,5-bis(4-methoxyphenyl)-3-methylpyrrolidine-2,4-dicarboxylate 
• 1012085-20-9 2-tert-butyl 4-methyl 5,5-bis(4-methoxyphenyl)-3-methylpyrrolidine-2,4-dicarboxylate 

Relevant academic research and scientific papers

Substrate-controlled diastereoselectivity switch in catalytic asymmetric direct mannich reaction of glycine derivatives with imines: from anti- to syn-α,β-diamino acids

(Chemical equation Presented) Back and forth: A diastereoselectivity switch has been devised in the Fesulphos-CuI-catalyzed glycine direct Mannich reaction with N-(8-quinolyl)sulfonyl imines by tuning the steric and electronic properties of the glycine component (see scheme). αβ-Diamino acids of syn configuration are produced under high diastereo- and enantiocontrol with glycinate esters derived from electron-deficient benzophenonetype ketimines, in contrast to aldiminederived pronucleophiles that lead to anti-configured products.