189886-25-7

Basic information

• Product Name: 2-Propenoic acid, 3-(4-broMophenyl)-, 1-Methylethyl ester, (2E)-
• Synonyms: 2-Propenoic acid, 3-(4-broMophenyl)-, 1-Methylethyl ester, (2E)-
• CAS NO: 189886-25-7
• Molecular Formula: C₁₂H₁₃BrO₂
• Molecular Weight: 269.13442
• Mol File: 189886-25-7.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-Propenoic acid, 3-(4-broMophenyl)-, 1-Methylethyl ester, (2E)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propenoic acid, 3-(4-broMophenyl)-, 1-Methylethyl ester, (2E)-(189886-25-7)
• EPA Substance Registry System: 2-Propenoic acid, 3-(4-broMophenyl)-, 1-Methylethyl ester, (2E)-(189886-25-7)

Safety Data

• Hazardous Substances Data: 189886-25-7(Hazardous Substances Data)

Upstream product

• 1200-07-3 trans-4-bromocinnamic acid 
• 67-63-0 isopropyl alcohol 

Downstream Products

• 189886-28-0 (E)-3-[4-(Dimethoxy-phosphoryl)-phenyl]-acrylic acid isopropyl ester 
• 1370259-90-7 (4-{1-(4,4-difluorocyclohexylcarbonylamino)-3-[3-(3-isopropyl-5-methyl-[1,2,4]triazol-4-yl)-8-azabicyclo[3.2.1]oct-8-yl]propyl}phenyl)carbamic acid tert-butyl ester 
• 1370259-79-2 C₄₅H₆₉F₂N₉O₇ 
• 1370259-95-2 (7-{2-[(4-{1-(4,4-difluorocyclohexylcarbonylamino)-3-[3-(3-isopropyl-5-methyl-[1,2,4]triazol-4-yl)-8-azabicyclo[3.2.1]oct-8-yl]propyl}phenylcarbamoyl)methoxy]acetylamino}heptyl)carbamic acid benzyl ester 
• 1370259-96-3 4,4-difluorocyclohexanecarboxamide N-{1-(4-{2-[(7-aminoheptylcarbamoyl)methoxy]acetylamino}phenyl)-3-[3-(3-isopropyl-5-methyl-[1,2,4]triazol-4-yl)-8-azabicyclo[3.2.1]oct-8-yl]propyl} 
• 1370259-80-5 4,4-difluorocyclohexanecarboxamide N-{1-(4-aminophenyl)-3-[3-(3-isopropyl-5-methyl-[1,2,4]triazol-4-yl)-8-azabicyclo[3.2.1]oct-8-yl]propyl} 
• 1370259-81-6 (4-{1-amino-3-[3-(3-isopropyl-5-methyl-[1,2,4]triazol-4-yl)-8-azabicyclo[3.2.1]oct-8-yl]propyl}phenyl)carbamic acid tert-butyl ester 
• 1370259-89-4 (4-{1-amino-3-[3-(3-isopropyl-5-methyl-[1,2,4]triazol-4-yl)-8-azabicyclo[3.2.1]oct-8-yl]-3-oxopropyl}phenyl)carbamic acid tert-butyl ester 
• 1370259-87-2 (4-{1-[benzyl(1-phenylethyl)amino]-3-[3-(3-isopropyl-5-methyl-[1,2,4]triazol-4-yl)-8-azabicyclo[3.2.1]oct-8-yl]-3-oxopropyl}phenyl)carbamic acid tert-butyl ester 
• 1370259-86-1 3-[benzyl-(1-phenyl-ethyl)-amino-3-(4-tert-butoxycarbonylamino-phenyl)]-propionic acid 
• 1370259-85-0 3-[benzyl-(1-phenyl-ethyl)-amino-3-(4-tert-butoxycarbonylamino-phenyl)]-propionic acid isopropyl ester 
• 189886-33-7 (E)-3-{4-[Hydroxy-(6-methoxy-1-methyl-1,2,3,4-tetrahydro-quinolin-3-ylmethoxy)-phosphoryl]-phenyl}-acrylic acid isopropyl ester 
• 189886-30-4 (E)-3-(4-Phosphono-phenyl)-acrylic acid isopropyl ester 
• 425431-88-5 (3R,αS,1'S,α'R)-tert-butyl 3-(N-benzyloxycarbonyl-N-α-methylbenzylamino)-3-[4-(3'-iso-propoxy-3'-oxo-1'-(N-benzyl-N-α-methylbenzylamino)propyl)phenyl]propanoate 

Relevant articles and documents

Carbocation Lewis Acid TrBF4-Catalyzed 1,2-Hydride Migration: Approaches to (Z)-α,β-Unsaturated Esters and α-Branched β-Ketocarbonyls

Carbocation Lewis acid TrBF4-catalyzed 1,2-hydride migration of α-alkyldiazoacetates themselves or in situ-generated cross-coupling adducts of aldehydes and α-alkyldiazoacetates has been developed, affording (Z)-α,β-unsaturated esters and α-branched β-ketocarbonyls, respectively, in good yields and with high regioselectivities.

Design and synthesis of a bivalent ligand to explore the putative heterodimerization of the mu opioid receptor and the chemokine receptor CCR5

The bivalent ligand approach has been utilized not only to study the underlying mechanism of G protein-coupled receptors dimerization and/or oligomerization, but also to enhance ligand affinity and/or selectivity for potential treatment of a variety of diseases by targeting this process. Substance abuse and addiction have made both the prevention and the treatment of human immunodeficiency virus (HIV) infection more difficult to tackle. Morphine, a mu opioid receptor (MOR) agonist, can accelerate HIV infection through up-regulating the expression of the chemokine receptor CCR5, a well-known co-receptor for HIV invasion to the host cells and this has been extensively studied. Meanwhile, two research groups have described the putative MOR-CCR5 heterodimers in their independent studies. The purpose of this paper is to report the design and synthesis of a bivalent ligand to explore the biological and pharmacological process of the putative MOR-CCR5 dimerization phenomenon. The developed bivalent ligand thus contains two distinct pharmacophores linked through a spacer; ideally one of which will interact with the MOR and the other with the CCR5. Naltrexone and Maraviroc were selected as the pharmacophores to generate such a bivalent probe. The overall reaction route to prepare this bivalent ligand was convergent and efficient, and involved sixteen steps with moderate to good yields. The preliminary biological characterization showed that the bivalent compound 1 retained the pharmacological characteristics of both pharmacophores towards the MOR and the CCR5 respectively with relatively lower binding affinity, which tentatively validated our original molecular design. The Royal Society of Chemistry 2012.