190000-01-2Relevant academic research and scientific papers
Novel bipolar phospholipids with different headgroups
Heiser, Ulrich F.,Dobner, Bodo
, p. 2025 - 2026 (1996)
The synthesis of long chain bipolar phospholipids with different polar headgroups and chain lengths of 16, 22 and 32 carbon atoms is described, using a Li2CuCl4-catalysed cross-coupling of Grignard reagents with ω-functionalised halogenoalkanes in order to synthesise unsymmetric bolaamphiphiles.
Copper-catalysed coupling of undec-10-enylmagnesium bromide with ω-functionalised halogenoalkanes as a key reaction for the synthesis of novel bipolar phospholipids with different head groups and chain length
Heiser, Ulrich F.,Dobner, Bodo
, p. 809 - 815 (2007/10/03)
The Grignard reagent from 11-bromoundec-1-ene undergoes copper-catalysed coupling with ω-functionalised halogenoalkanes of different chain length to provide long-chain ω-substituted alkenes. The reaction conditions for this have been studied to optimise the products yields, especially those for the preparation of the C32 unit. Functionalised alkenes are suitable building blocks for the direct synthesis of bipolar phospholipids with different head groups.
