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Usage

Uses

Used in Pharmaceutical and Agrochemical Industries:
Benzonitrile, 2-amino-4,6-difluoro(9CI), is utilized as a key intermediate in the synthesis of various pharmaceuticals and agrochemicals. Its unique structure allows for the development of new drugs and pesticides with improved efficacy and selectivity.
Used in Materials Science:
In the field of materials science, Benzonitrile, 2-amino-4,6-difluoro(9CI), is employed as a building block for the creation of novel materials with specific properties. Its incorporation into polymers and other materials can enhance their performance, such as thermal stability, chemical resistance, and mechanical strength.
Used in Organic Synthesis:
Benzonitrile, 2-amino-4,6-difluoro(9CI), serves as a versatile starting material in organic synthesis, enabling the production of a wide range of organic compounds. Its reactivity and functional groups make it suitable for various synthetic routes, including cross-coupling reactions, nucleophilic substitutions, and electrophilic aromatic substitutions.
Used in Antimicrobial Applications:
Benzonitrile, 2-amino-4,6-difluoro(9CI), has been studied for its biological and pharmacological activities, particularly its potential as an antibacterial and antifungal agent. Its unique structure allows it to target and inhibit essential cellular processes in microorganisms, making it a promising candidate for the development of new antimicrobial agents to combat drug-resistant infections.
It is crucial to handle Benzonitrile, 2-amino-4,6-difluoro(9CI), with care, as it may pose hazards to human health and the environment. Proper safety measures and disposal methods should be followed to minimize potential risks associated with Benzonitrile, 2-amino-4,6-difluoro- (9CI).

Upstream product

• 96606-37-0 2,4,6-trifluorobenzonitrile 

Downstream Products

• 154314-61-1 4-amino-2,6-difluorobenzamide 
• 893428-66-5 2-amino-4,6-difluoro-benzamide 
• 126674-77-9 2-amino-4,6-difluorobenzoic acid 

Relevant academic research and scientific papers

On the Synthesis of 2-Amino-4,6-difluorobenzonitrile: Highly Selective Formation of 5-Fluoro-3-nitro-1,2-benzoquinone 2-Diazide in the Attempted Sandmeyer Cyanation of 2,4-Difluoro-6-nitrobenzenediazonium Cation

Attempted cyanation of a diazonium salt derived from 2,4-difluoro-6-nitroaniline gives 5-fluoro-3-nitro-1,2-benzoquinone 2-diazide? in good yield by selective nucleophilic substitution of the 2-fluoride group by hydroxide, instead of the desired 2-amino-4

ERBB RECEPTOR INHIBITORS

Disclosed are compounds inhibiting ErbBs (e. g. HER2), pharmaceutically acceptable salts, hydrates, solvates or stereoisomers thereof and pharmaceutical compositions comprising the compounds. The compound and the pharmaceutical composition can effectively treat diseases associated ErbBs (especially HER2), including cancer.

Design, structure-activity relationships and in vivo characterization of 4-Amino-3-benzimidazol-2-ylhydroquinolin-2-ones: Novel class of receptor tyrosine kinase inhibitors

The inhibition of key receptor tyrosine kinases (RTKs) that are implicated in tumor vasculature formation and maintenance, as well as tumor progression and metastasis, has been a major focus in oncology research over the last several years. Many potent small molecule inhibitors of vascular endothelial growth factor receptor (VEGFR) and platelet-derived growth factor receptor (PDGFR) kinases have been evaluated. More recently, compounds that act through the complex inhibition of multiple kinase targets have been reported and may exhibit improved clinical efficacy. We report herein a series of potent, orally efficacious 4-amino- 3-benzimidazol-2-ylhydroquinolin-2-one analogues as inhibitors of VEGF, PDGF, and fibroblast growth factor (FGF) receptor tyrosine kinases. Compounds in this class, such as 5 (TKI258), are reversible ATP- competitive inhibitors of VEGFR-2, FGFR-1, and PDGFRβ with IC50 values 0.1 μM. On the basis of its favorable in vitro and in vivo properties, compound 5 was selected for clinical evaluation and is currently in phase I clinical trials.

CHEMICAL PROCESS

The present invention relates to chemical processes useful in the manufacture of the compound 4-(6-chloro-2,3-methylenedioxyanilino)-7-[2-(4-methylpiperazin-1-yl)ethoxy]- 5-tetrahydropyran-4-yloxyquinazoline (the active entity within AZD0530), to intermed

Pharmaceutically active compounds

Compounds of formula (I) wherein: R1 and R19 independently represent hydrogen, alkyl C1-6, alkoxy C1-6, alkylthio C1-6, halogen, hydroxyl or amino; R2 represents H or alkyl; R3 represents phenyl, a 6-membered heterocyclic aromatic ring containing one or two nitrogen atoms, or a 5-membered heterocyclic aromatic ring containing 1 to 3 heteroatoms selected from O,N, and S, which phenyl or heterocyclic aromatic ring may be optionally substituted by alkyl C1-6, alkoxy C1-6, haologen, hydroxyl, alkylthio C1-6, cyano, trifluoromethyl, nitro, hydroxymethyl, amino, a group --(CH2)c NHCO2 R10, a group --(CH2)c NR5 R6, or a group --CO2 R11 ; or R3 represents hydrogen or alkyl C1-8, which alkyl group may be optionally substituted by amino or a group --NHCO2 R10 ; R4 represents hydrogen or alkyl C1-6; or R3 and R4 taken together represent a group (CH2)a Z(CH2)b ; c represents an integer 0 to 2; and pharmaceutically acceptable salts thereof, have been found to be useful as a pharmaceuticals. The compounds may especially be used in the treatment of inflammatory disorders.