190012-47-6

Usage

Explanation

The molecular formula represents the number of atoms of each element present in a molecule. In this case, the compound has 18 carbon (C), 20 hydrogen (H), 2 chlorine (Cl), and 3 oxygen (O) atoms.

Explanation

The compound has two fused rings a 1,4-dioxane ring, which is a six-membered ring containing two oxygen atoms, and an azaspirodecane ring, which is a seven-membered ring containing one nitrogen atom.

Explanation

The azaspirodecane ring has a 3,4-dichlorobenzoyl group attached to it. This group consists of a benzene ring with two chlorine atoms at the 3rd and 4th positions and a carbonyl (C=O) group attached to the benzene ring.

Explanation

The 3,4-dichlorobenzoyl group is attached to the eighth carbon atom of the azaspirodecane ring.

Explanation

Due to its unique structure and properties, 1,4-Dioxa-8-azaspiro[4.5]decane, 8-(3,4-dichlorobenzoyl)- may have potential applications in various fields, such as the development of new drugs, agrochemicals for pest control, or other industrial processes.

Class

Spiro compounds

Structural components

1,4-dioxane ring and azaspirodecane ring

Substituent

3,4-dichlorobenzoyl group

Position of substituent

Eighth position on the azaspirodecane ring

Potential applications

Pharmaceuticals, agrochemicals, and other industrial uses

Upstream product

• 177-11-7 4,4-ethylenedioxy-piperidine 
• 3024-72-4 3,4-dichlorobenzoyl chloride 

Downstream Products

• 223632-67-5 N-(3,4-dichlorobenzoyl)-piperidin-4-one 
• 208111-52-8 N-(3,4-dichlorobenzoyl)-1-oxa-6-azaspiro<2,5>octane 
• 208111-40-4 N-(3,4-dichlorobenzoyl)-4-fluoro-4-aminomethylpiperidine 
• 223632-79-9 N-(3,4-dichlorobenzoyl)-4-fluoro-4-hydroxymethylpiperidine 
• 223633-21-4 N-(3,4-dichlorobenzoyl)-4-azidomethyl,4-hydroxypiperidine 
• 223633-05-4 N-(3,4-dichlorobenzoyl)-4-azidomethyl,4-methoxypiperidine 
• 208111-55-1 N-(3,4-dichlorobenzoyl)-4-fluoro-4-(4-methylphenylsulonuloxymethyl)-piperidine 
• 223632-92-6 N-(3,4-dichlorobenzoyl)-4-fluoro-4-phthalimidomethylpiperidine 

Relevant academic research and scientific papers

Novel derivatives of 2-pyridinemethylamine as selective, potent, and orally active agonists at 5-HT(1A) receptors

The aim of this work was to improve the oral bioavailability of a recently discovered, novel structural class of 5-HT(1A) receptor agonists: aryl-{[4-(6-R-pyridin-2-ylmethyl)-amino]-methyl}piperidin-1-yl-methanone. Incorporation of a fluorine atom in the β-position to the amino function in the side chain led to analogues that exhibited, in general, enhanced and long-lasting 5-HT(1A) agonist activity in rats after oral administration. Location of the fluorine atom at the C-4 position of the piperidine ring was the most favorable, and among the various substituents tested, the ability of the fluorine was unique in improving the oral activity of this family of ligands. Thus, the derivatives 39, 46, and 61 bound with higher affinity and selectivity to 5-HT(1A) receptors (versus dopaminergic D2 and adrenergic α1 receptors) and displayed more potent 5-HT(1A) agonist activity in vitro and in vivo than their C-4 desfluoro analogues. To examine the relationship between the conformation of the pharmacophore and the level of agonistic activity of this type of ligand, we synthesized a series of 3-chloro-4- fluorophenyl-(4-fluoro-4{[(5-(H or CH3)-6-R-pyridin-2-ylmethyl)-amino]- methyl}-piperidin-1-yl-methanone derivatives and found that the combination of a 5-methyl and a 6-methylamino substituent on the pyridine ring synergistically affected their 5-HT(1A) agonist properties. Thus, the 3- chloro-4-fluorophenyl-(4-fluoro-4{[(5-methyl-6-methylamino-pyridin-2- ylmethyl)-amino]-methyl}-piperidin-1-yl-methanone 40 behaved as a more potent 5-HT(1A) receptor agonist in vitro and in vivo than its 5- unsubstituted analogue 38. The antidepressant potential of the lead compounds 40, 45, and 54 was examined by means of the forced swimming test (FST) in rats. The results indicated that, after a single oral administration, these compounds inhibited immobility in the FST more potently and more extensively than the clinically used antidepressant imipramine. Thus, 40, 45, and 54 are potent, orally active 5-HT(1A) receptor agonists with marked antidepressant potential.