19006-80-5

Basic information

• Product Name: 1-(4-methylphenyl)-1,2-dihydropyridin-2-one
• Synonyms: 1-(4-methylphenyl)-1,2-dihydropyridin-2-one
• CAS NO: 19006-80-5
• Molecular Weight: 185.225
• Mol File: 19006-80-5.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: 1-(4-methylphenyl)-1,2-dihydropyridin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-methylphenyl)-1,2-dihydropyridin-2-one(19006-80-5)
• EPA Substance Registry System: 1-(4-methylphenyl)-1,2-dihydropyridin-2-one(19006-80-5)

Safety Data

• Hazardous Substances Data: 19006-80-5(Hazardous Substances Data)

Upstream product

• 142-08-5 2-Pyridone 
• 23353-96-0 pyridin-2(3H)-one 
• 106-43-4 para-chlorotoluene 
• 106-38-7 para-bromotoluene 
• 5720-05-8 4-methylphenylboronic acid 
• 142-08-5 2-hydroxypyridin 
• 624-31-7 4-tolyl iodide 

Relevant articles and documents

An efficient copper-catalyzed coupling reaction of pyridin-2-ones with aryl and heterocyclic halides based on Buchwald's protocol

An efficient copper-catalyzed coupling reaction based on the Buchwald's protocol has been established for pyridin-2-ones with aryl iodides, aryl bromides, and heterocyclic bromides.

Substituent Effects of 2-Pyridones on Selective O-Arylation with Diaryliodonium Salts: Synthesis of 2-Aryloxypyridines under Transition-Metal-Free Conditions

An efficient transition-metal-free strategy to synthesize 2-aryloxypyridine derivatives has been developed by a selective O-arylation of 2-pyridones with diaryliodonium salts. The reaction was compatible with a series of functional groups for 2-pyridones and diaryliodonium salts such as halides, nitro, cyano, and ester groups. The substituents at the C6-position of 2-pyridones favored O-arylation products because of steric hindrance. The reaction was easily performed on a gram-scale and 6-chloro-2-pyridone was a good precursor to access various unsubstituted 2-aryloxypyridines by dehalogenation. A P2Y 1 lead compound analogue could be prepared in good yield over two steps.

N-arylation of pyridin-2(1H)-ones with pentavalent organobismuth reagents under copper-free conditions

An efficient method for the N-arylation of pyridin-2(1H)-ones and the related heteroaromatic lactams has been established via ligand-coupling reactions using tri- or tetra-aryl organobismuth(V) reagents such as triarylbismuth dichlorides. Also, N-alkenylation of pyridin-2(1H)-one was achieved similarly by using alkenyltriarylbismuth(V) reagents.