190078-45-6 Usage
Chemical Properties
Pale Yellow Solid
Uses
Different sources of media describe the Uses of 190078-45-6 differently. You can refer to the following data:
1. ent-Montelukast Sodium Salt (Montelukast EP Impurity A) is the S-enantiomer of Montelukast. Results indicate that there is no apparent bioinversion of Montelukast to its S-enantiomer in humans.
2. The S-enantiomer of Montelukast. Results indicate that there is no apparent bioinversion of Montelukast to its S-enantiomer in humans.
Check Digit Verification of cas no
The CAS Registry Mumber 190078-45-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,9,0,0,7 and 8 respectively; the second part has 2 digits, 4 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 190078-45:
(8*1)+(7*9)+(6*0)+(5*0)+(4*7)+(3*8)+(2*4)+(1*5)=136
136 % 10 = 6
So 190078-45-6 is a valid CAS Registry Number.
InChI:InChI=1/C35H36ClNO3S.Na/c1-34(2,40)30-9-4-3-7-25(30)13-17-32(41-23-35(18-19-35)22-33(38)39)27-8-5-6-24(20-27)10-15-29-16-12-26-11-14-28(36)21-31(26)37-29;/h3-12,14-16,20-21,32,40H,13,17-19,22-23H2,1-2H3,(H,38,39);/q;+1/p-1/b15-10+;/t32-;/m0./s1
190078-45-6Relevant articles and documents
Identification, synthesis and characterization of impurities of Montelukast sodium
Sunil Kumar,Anjaneyulu,Hima Bindu
, p. 4536 - 4546 (2012/02/04)
Montelukast sodium is a selective leukotriene receptor antagonist which inhibits cysteinyl leukotriene CysLT1 receptor. Various synthesis of Montelukast is published. During laboratory optimization and later in bulk synthesis formation of various impurities was detected. Besides, pharma Europa draft mention nine process related impurities. However, the method of preparation of most of these impurities is not available in literature. Also, different route of synthesis will have different impurity profile and those process related impurities are not covered in pharmacopeias. In this study we report the synthesis of possible process impurities, including seven impurities (A-H) mentioned in pharma Europa.