190078-68-3

Upstream product

• 555-16-8 4-nitrobenzaldehdye 
• 621-84-1 O-benzyl carbamate 
• 644-97-3 Dichlorophenylphosphine 
• 1027820-93-4 C₂₁H₁₈ClN₂O₅P 

Downstream Products

• 196806-20-9 [Benzyloxycarbonylamino-(4-nitro-phenyl)-methyl]-phenyl-phosphinic acid methyl ester 
• 196806-22-1 C₅₀H₅₂N₄O₁₀P₂S₂ 
• 196806-24-3 C₃₂H₃₆N₄O₆P₂S₂ 
• 374789-13-6 4-{4-[benzyloxycarbonylamino-(hydroxy-phenyl-phosphinoyl)-methyl]-phenylcarbamoyl}-butyric acid 
• 196806-21-0 [(4-amino-phenyl)-benzyloxycarbonylamino-methyl]-phenyl-phosphinic acid methyl ester 
• 196806-25-4 [(4-amino-phenyl)-benzyloxycarbonylamino-methyl]-phenyl-phosphinic acid 

Relevant academic research and scientific papers

Catalytic antibodies induced by a zwitterionic hapten

A zwitterionic hapten 4 featuring both positively and negatively charged functional groups was designed and synthesized with the goal of generating catalytic antibodies for the hydrolysis of ester 6 and amide 7. Of the 36 monoclonal antibodies specific to BSA-4 (bovine serum albumin) that were isolated, six accelerated the hydrolysis of 6. Two catalytic antibodies with distinctively different and representative kinetic behaviors were selected for detailed kinetic studies. Whereas H8-2-6F11 showed burst kinetic behavior, which can be attributed to the formation of an acyl intermediate, H8-1-2D5 did not, but it did exhibit high multiple turnover activity. The rate of hydrolysis of 6 catalyzed by H8-1-2D5 followed Michaelis-Menten kinetics; the apparent values of the Michaelis-Menten constant Km and the catalytic constant kcat were 488 μM and 3.5 min-1 respectively. The catalytic rate enhancement (kcat/kun) observed for H8-1-2D5 was 1.3 × 105, which is approximately two orders of magnitude greater than those for monofunctional haptens. Thus H8-1-2D5 compares well in catalytic activity with antibodies isolated by a related approach called heterologous immunization.

A convenient synthesis of phenyl-α-(benzyloxycarbonylamino)benzylphosphinic acids

A series of phenyl α-(benzyloxycarbonylamino)benzylphosphinic acids are prepared from benzyl carbamate, substituted benzaldehydes and phenyldichlorophosphine in acetyl chloride via the corresponding phosphinic chloride 4. The reaction proceeds smoothly at

A facile synthesis of phenyl 1-benzyloxycarbonylamino arylmethylphosphinopeptide derivatives

With acetyl chloride as the solvent, benzyl carbamate reacted with aromatic aldehyde and dichlorophenylphosphine to give phenyl 1-aryl methylphosphinic chloride, which reacted with an amino acid ester to give corresponding phosphinopeptide derivatives.