19010-47-0Relevant academic research and scientific papers
Novel compounds containing multiple guanide groups that bind the HIV coreceptor CXCR4
Wilkinson, Royce A.,Pincus, Seth H.,Shepard, Joyce B.,Walton, Sarah K.,Bergin, Edward P.,Labib, Mohamed,Teintze, Martin
experimental part, p. 255 - 263 (2011/12/15)
The G-protein-coupled receptor CXCR4 acts as a coreceptor for human immunodeficiency virus type 1 (HIV-1) infection, as well as being involved in signaling cell migration and proliferation. Compounds that block CXCR4 interactions have potential uses as HI
One-pot two-step solvent-free rapid and clean synthesis of 2-(substituted amino)pyrimidines by microwave irradiation
Goswami, Shyamaprosad,Hazra, Anita,Jana, Subrata
experimental part, p. 1175 - 1181 (2009/12/25)
abs A series of diversely 2-(substituted amino)pyrimidines (along with ring substitution) has been synthesized under solvent- and catalyst-free microwave conditions from substituted guanidines and β-diketones. The substituted guanidines are synthesized from (S)-methylisothiourea sulfate and different amines (various alkyl, aryl, or heterocyclic and also chiral amines) under microwave irradiation. These two-step reactions are performed in one-pot without isolating any intermediate. This protocol has been successfully applied for the synthesis of bisaminopyrimidines and 2-substituted aminopyrimidines containing chiral moiety where chirality remains undisturbed.
