19011-66-6

Basic information

• Product Name: 3,5-Diphenylbarbituric acid
• Synonyms: 1,5-Diphenylbarbituric acid;3,5-Diphenylbarbituric acid
• CAS NO: 19011-66-6
• Molecular Formula: C₁₆H₁₂N₂O₃
• Molecular Weight: 280.2781
• Mol File: 19011-66-6.mol
• Article Data: 1

Chemical Properties

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: 1.325g/cm³
• Refractive Index: 1.623
• CAS DataBase Reference: 3,5-Diphenylbarbituric acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3,5-Diphenylbarbituric acid(19011-66-6)
• EPA Substance Registry System: 3,5-Diphenylbarbituric acid(19011-66-6)

Safety Data

• Hazardous Substances Data: 19011-66-6(Hazardous Substances Data)

Usage

InChI:InChI=1/C16H12N2O3/c19-14-13(11-7-3-1-4-8-11)15(20)18(16(21)17-14)12-9-5-2-6-10-12/h1-10,13H,(H,17,19,21)

Upstream product

• 64-10-8 phenyl carbamate 
• 83-13-6 diethyl 2-phenylmalonate 

Downstream Products

• 221679-71-6 5-amino-1,5-diphenyl-pyrimidine-2,4,6-trione 
• 221679-73-8 5-Azido-1,5-diphenylbarbituric acid 
• 569337-10-6 1-benzyl-5-phenyl-5-phenylcarbamoylhydantoin 
• 569336-93-2 5-benzylamino-1,5-diphenylbarbituric acid 
• 569337-08-2 5-phenyl-5-phenylcarbamoyl-1-propylhydantoin 
• 569336-91-0 1,5-diphenyl-5-propylaminobarbituric acid 
• 569336-92-1 1,5-diphenyl-5-isopropylaminobarbituric acid 
• 569336-75-0 5-bromo-1,5-diphenylbarbituric acid 

Relevant articles and documents

A new one-pot synthesis of 5,5-disubstituted hydantoins from diethyl acetamidomalonates and ureas

A new one-pot synthesis of 5,5-disubstituted hydantoins 3 is reported. Diethyl 2-acetamido-2-alkylmalonates were found to react with substituted ureas in the presence of sodium ethoxide to produce the 5-alkyl-5- carbamoylhydantoins 3 a-e. The reaction involves a ring contraction of intermediate 5-aminobarbituric acids to the final hydantoin derivatives. The 5-aminobarbituric acids 2 d-f were prepared from azido derivatives 6 d-f. On treatment with sodium ethoxide, 2 d-f underwent the rearrangement to afford the hydantoins 3 d-f.