190141-90-3

Upstream product

• 190142-02-0 ((S)-1-{1-[(3R,S)-((S)-2-benzyloxycarbonylamino-4-methylpentanoylamino)-(4R,S)-hydroxypyrrolidin-1-yl]methanoyl}-3-methylbutyl)carbamic acid benzyl ester 
• 2018-66-8 Z-Leu-OH 
• 190142-00-8 (3R,S)-((S)-2-benzyloxycarbonylamino-4-methylpentanoylamino)-(4R,S)-4-hydroxypyrrolidine-1-carboxylic acid tert-butyl ester 
• 749188-99-6 [(S)-1-(4-Hydroxy-pyrrolidin-3-ylcarbamoyl)-3-methyl-butyl]-carbamic acid benzyl ester 

Relevant academic research and scientific papers

Cyclic ketone inhibitors of the cysteine protease cathepsin K

Cathepsin K (EC 3.4.22.38), a cysteine protease of the papain superfamily, is predominantly expressed in osteoclasts and has been postulated as a target for the treatment of osteoporosis. Crystallographic and structure-activity studies on a series of acyc