190193-11-4

Upstream product

• 598-21-0 2-Bromoacetyl bromide 
• 131865-54-8 4-(([¹⁸F]-fluoro)phenyl)methanamine 
• 81755-10-4 4-[18F]fluorobenzonitrile 

Relevant academic research and scientific papers

A general method for labeling oligodeoxynucleotides with 18F for in vivo PET imaging

This paper describes an original general method for the synthesis of oligodeoxynucleotides (ODNs) carrying the positron emitter 18F. The labeling strategy developed is simple, reliable, independent of backbone modifications and base sequence. I

Novel 18F Labeling Strategy for Polyester-Based NPs for in Vivo PET-CT Imaging

Drug-loaded nanocarriers and nanoparticulate systems used for drug release require a careful in vivo evaluation in terms of physicochemical and pharmacokinetic properties. Nuclear imaging techniques such as positron emission tomography (PET) are ideal and

Synthesis and application of 4-[18F]fluorobenzylamine: A versatile building block for the preparation of PET radiotracers

A novel synthesis of 4-[18F]fluorobenzylamine ([ 18F]FBA) by means of transition metal-assisted sodium borohydride reduction of 4-[18F]fluorobenzonitrile ([18F]FBN) is described. This approach could successfully

Automated radiosynthesis of N-(4-[18F]fluorobenzyl)-2- bromoacetamide: An F-18-labeled reagent for the prosthetic radiolabeling of oligonucleotides

The potential for radiolabeled antisense oligonucleotides to image gene expression combined with the enhanced resolution of positron-emission tomography justifies the continued interest in the development of oligonucleotides tagged with positron-emitting

Fluorine-18 labelling of PNAs functionalized at their pseudo-peptidic backbone for imaging studies with PET

Peptide nucleic acids (PNAs) form a unique class of synthetic macromolecules, originally designed as ligands for the recognition of double-stranded DNA, where the deoxyribose phosphate backbone of original DNA is replaced by a pseudo-peptide N-(2-aminoeth

Fluorine-18- and iodine-125-labelling of spiegelmers

Spiegelmers are high-affinity L-enantiomeric oligonucleotide ligands (aptamers) that display high resistance to enzymatic degradation compared to D-oligonucleotides. Spiegelmers belong to the third generation of aptamers, and are currently extensively inv

Fluorine-18 labelling of oligonucleotides: Prosthetic labelling at the 5′-end using the N-(4-[18F]fluorobenzyl)-2-bromoacetamide reagent

Labelled oligonucleotides are new imaging tools to study gene expression at the nucleic acid and protein levels. We have previously developed a universal method to label oligonucleotides at their 3′-end with radiohalogens and particularly with fluorine-18

Fluorine-18 labeling of peptide nucleic acids

Peptide nucleic acids (PNAs) are a unique class of synthetic macromolecules, originally designed as ligands for the recognition of double stranded DNA. From a chemical point of view, the deoxyribose phosphate backbone of DNA is replaced by a pseudo-peptid

Fluorine-18 labeling of oligonucleotides bearing chemically - Modified ribose - Phosphate backbones

We have recently described the labeling of a natural deoxyribose phosphodiester oligonucleotide with fluorine-18 (t1/2 : 109.8 min) and demonstrated its potential for in vivo imaging in a primate PET study. We here report that the methodology e