190197-83-2

Upstream product

• 1126-09-6 4-carbethoxypiperidine 
• 3874-54-2 4-(4-fluorophenyl)-4-oxo-n-butyl chloride 
• 498-94-2 isonipecotic acid 

Downstream Products

• 190197-84-3 1-[4-(4-Fluoro-phenyl)-4-oxo-butyl]-piperidine-4-carboxylic acid 

Relevant academic research and scientific papers

Synthesis of spin labels for ESR imaging of living rat head

Spin labels (7, 10, 13, 16, 22, 27) were synthesized from piperidinyloxyl (1), pyrrolidinyloxyl (2), and oxazolidinyloxyl (3). These compounds were injected into the carotid artery of anesthetized rats, and the ESR spectra of the rat brain were immediately recorded by the use of an L- band ESR spectrometer. Based on the spectra obtained, we considered whether or not these spin labels can pass the blood brain barrier and bind to brain tissue components.

Synthesis and SAR studies of 1-substituted-n-(4-alkoxycarbonylpiperidin-1-yl)alkanes as potent antiarrhythmic agents

Synthesis and SAR studies of the title compounds have resulted in the identification of structural and physicochemical parameter (Vw) contributing for antiarrhythmic activity. Among the two most promising compounds 3a and 3b, the 3a has shown antiarrhythmic activity comparable to quinidine.