19024-47-6Relevant academic research and scientific papers
Enantioselective synthesis of phomallenic acid C by In- and Pd-mediated anti-SN2′ coupling
Kato, Tomoko,Ishigami, Ken,Akasaka, Kazuaki,Watanabe, Hidenori
, p. 6953 - 6958 (2009)
Enantioselective synthesis of phomallenic acid C, an inhibitor of bacterial FAS II pathway, was succeeded. Allenyldiyne structure was constructed by a direct anti-SN2′ coupling of propargyl mesylate with diynylindium in the presence of palladiu
Stereoselective total synthesis of (S)-Virol C and (S)-1-dehydroxyvirol A
Fiandanese, Vito,Bottalico, Daniela,Cardellicchio, Cosimo,Marchese, Giuseppe,Punzi, Angela
, p. 4551 - 4556 (2007/10/03)
A stereoselective total synthesis of (S)-Virol C and (S)-1-dehydroxyvirol A has been developed, based upon the selective and sequential substitution of the two trimethylsilyl groups of readily available 1,4-bis(trimethylsilyl)-1,3- butadiyne.
New stereoselective methodology for the synthesis of dihydroxerulin and xerulin, potent inhibitors of the biosynthesis of cholesterol
Fiandanese, Vito,Bottalico, Daniela,Marchese, Giuseppe,Punzi, Angela
, p. 11421 - 11425 (2007/10/03)
A new stereoselective methodology for the synthesis of both dihydroxerulin and xerulin has been devised. The key step required cross-coupling reactions between the bromo trienyne, (1E,3E,5E)-1-bromo-8-trimethylsilyl-1,3,5-octatrien- 7-yne and the appropriate conjugated diynes. The palladium-catalyzed tandem cross-coupling/cyclization reaction of the resulting polyenynes with (Z)-3-iodo-2-propenoic acid led directly to dihydroxerulin or xerulin with a high degree of stereoselectivity. A new stereoselective methodology has been devised for the total synthesis of both dihydroxerulin and xerulin.
