19024-68-1Relevant academic research and scientific papers
PHENYL SULFONAMIDE ENDOTHELIN ANTAGONISTS
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, (2008/06/13)
Compounds of the formula STR1 inhibit the activity of endothelin. The symbols are defined as follows: R 1, R 2 and R. sup.3 are each independently(a) hydrogen, except that R. sup.1 is other than hydrogen;(b) alkyl, alkenyl, alkynyl, alkoxy, cycloalkyl, cycloalkylalkyl, cycloalkenyl, cycloalkenylalkyl, aryl, aryloxy, aralkyl or aralkoxy, any of which may be substituted with Z 1, Z 2 and Z. sup.3 ;(c) halo;(d) hydroxyl;(e) cyano; (f) nitro; (g)--C(O)H or--C(O)R 6 ;(h)--CO 2 H or--CO 2 R 6 ; (i)--SH,--S(O) n R 6,--S(O) m--OH,--S(O) m--OR 6,--O--S(O) m--R 6,--O--S(O) m OH or--O--S(O) m--OR. sup.6 ;(j)--Z. sup.4--NR 7 R 8 ; or (k)--Z 4--N(R 11--Z 5--NR 9 R 10 ; and the remaining symbols are as defined in the specification.
ISOLATION OF AMINOARYLSULFONATES BY ALKALINE AGENTS FROM THE REACTION MEDIUM DURING HIGH-TEMPERATURE SULFONATION OF AMINES IN o-DICHLOROBENZENE.
Matveev,Okhterova,Chalykh,Gradov
, p. 1073 - 1075 (2007/10/02)
A reaction mass containing the aminoarylsulfonic acid, unconverted amine in the form of amine sulfates, and products of amine resinification is formed during synthesis of aminoarylsulfonic acids by thermal conversion of amine sulfates in a high-boiling so
