19026-31-4

Basic information

• Product Name: taxodione
• Synonyms: taxodione;(4bS,8aS)-4b,5,6,7,8,8a-Hexahydro-4-hydroxy-2-isopropyl-4b,8,8-trimethylphenanthrene-3,9-dione;11-Hydroxyabieta-7,9(11),13-triene-6,12-dione
• CAS NO: 19026-31-4
• Molecular Formula: C20H26O3
• Molecular Weight: 314.41864
• Mol File: 19026-31-4.mol
• Article Data: 6

Chemical Properties

• Melting Point: 115-116°
• Boiling Point: 469.8°Cat760mmHg
• Flash Point: 252.1°C
• Appearance: /
• Density: 1.14g/cm³
• Vapor Pressure: 8.42E-11mmHg at 25°C
• Refractive Index: 1.563
• PKA: 4.50±1.00(Predicted)
• CAS DataBase Reference: taxodione(CAS DataBase Reference)
• NIST Chemistry Reference: taxodione(19026-31-4)
• EPA Substance Registry System: taxodione(19026-31-4)

Safety Data

• Hazardous Substances Data: 19026-31-4(Hazardous Substances Data)

Usage

Cytotoxicity

IC50 (μg/mL): 2.45 (WM-115), 2.21(HL-60), 2.06 (NALM-6), 12.61(HUVEC) (Ku?ma et al. 2012).IC50 (μg/mL): 18.97 (K562), 17.79(HL-60) (Tayarani-Najaran et al. 2013).

InChI:InChI=1/C20H26O3/c1-11(2)13-9-12-10-14(21)18-19(3,4)7-6-8-20(18,5)15(12)17(23)16(13)22/h9-11,18,23H,6-8H2,1-5H3

Upstream product

• 86510-12-5 (S)-2-Isopropyl-4b,8,8-trimethyl-4b,5,6,7,8,8a,9,10-octahydro-phenanthrene-3,4-dione 
• 86510-11-4 (S)-7-Isopropyl-5,6,10-trimethoxy-1,1,4a-trimethyl-1,2,3,4,4a,9,10,10a-octahydro-phenanthren-9-ol 
• 514-62-5 furreginol 
• 86000-24-0 2-(2,3-dimethoxy-4-isopropylphenyl)-2,6,6-trimethylcyclohexylethanoic acid 
• 86000-25-1 methyl 2-(2,3-dimethoxy-4-isopropylphenyl)-2,6,6-trimethylcyclohexylethanoate 
• 52567-84-7 7-oxo-11,12-dimethoxyabieta-8,11,13-triene 
• 86510-09-0 (R)-10-Hydroxy-7-isopropyl-5,6-dimethoxy-1,1,4a-trimethyl-2,3,4,4a-tetrahydro-1H-phenanthren-9-one 
• 86510-10-3 (R)-7-Isopropyl-5,6,10-trimethoxy-1,1,4a-trimethyl-2,3,4,4a-tetrahydro-1H-phenanthren-9-one 
• 64158-69-6 (S)-3-Hydroxy-2-isopropyl-4b,8,8-trimethyl-4b,6,7,8,8a,10-hexahydro-5H-phenanthren-9-one 
• 120665-72-7 (S)-2-Isopropyl-4b,8,8-trimethyl-4a,4b,5,6,7,8,8a,9-octahydro-4H-phenanthren-3-one 
• 34539-84-9 12-hydroxysimonellite 
• 120665-68-1 (3S,4bS)-2-Isopropyl-4b,8,8-trimethyl-3,4,4a,4b,5,6,7,8,8a,9-decahydro-phenanthren-3-ol 
• 22160-86-7 Acetic acid (S)-2-isopropyl-4b,8,8-trimethyl-4b,5,6,7,8,8a-hexahydro-phenanthren-3-yl ester 
• 120665-84-1 Acetic acid (S)-2-isopropyl-4b,8,8-trimethyl-9-oxo-4b,5,6,7,8,8a,9,10-octahydro-phenanthren-3-yl ester 

Related news

An unusual taxodione (cas 19026-31-4) derivative from hairy roots of Salvia austriaca07/23/2019

From a root culture of Salvia austriaca, transformed with Agrobacterium rhizogenes, a new diterpenoid was isolated and its chemical structure was determined as 7-(2-oxohexyl)-11-hydroxy-6, 12-dioxo-7,9(11),13- abietatriene [= 7-(2-oxohexyl)-taxodione] on the basis of spectroscopic methods, espec...detailed

taxodione (cas 19026-31-4) induces apoptosis in BCR-ABL-positive cells through ROS generation07/22/2019

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Relevant articles and documents

SYNTHESIS OF (+)-TAXODIONE FROM (-)-ABIETIC ACID

A new stereoselective synthesis of (+)-taxodione (1) from (-)-abietic acid (2) via the iron carbonyl complex 3 is described.

Synthesis of variously oxidized abietane diterpenes and their antibacterial activities against MRSA and VRE

Variously oxidized 12 natural abietanes, 6,7-dehydroferruginol methyl ether (3), ferruginol (5), 11-hydroxy-12-oxo-7,9(11),13-abietatriene (7), royleanone (9), demethyl cryptojaponol (12), salvinolone (14), sugiol methyl ether (16), sugiol (17), 5,6-dehyd

Alternate Syntheses of Taxodione

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