190269-95-5Relevant academic research and scientific papers
Asymmetric bioreduction of α,β-unsaturated nitriles and ketones
Kosjek, Birgit,Fleitz, Fred J.,Dormer, Peter G.,Kuethe, Jeffrey T.,Devine, Paul N.
, p. 1403 - 1406 (2008/12/20)
Two applications for the asymmetric reduction of activated alkenes employing isolated enoate reductases are reported. A series of α,β-unsaturated nitriles were shown to be converted to the optically active nitrile products in high yields and excellent enantioselectivities (up to 99% ee). In addition, the reduction of 2,3-disubstituted cyclopentenones was shown to provide almost exclusively trans-2,3-disubstituted cyclopentanones in high yield and enantiopurity (94% ee).
