190270-76-9Relevant academic research and scientific papers
Carboxylated, heteroaryl-substituted chalcones as inhibitors of vascular cell adhesion molecule-1 expression for use in chronic inflammatory diseases
Meng, Charles Q.,Ni, Liming,Worsencroft, Kimberly J.,Ye, Zhihong,Weingarten, M. David,Simpson, Jacob E.,Skudlarek, Jason W.,Marino, Elaine M.,Suen, Ki-Ling,Kunsch, Charles,Souder, Amy,Howard, Randy B.,Sundell, Cynthia L.,Wasserman, Martin A.,Sikorski, James A.
, p. 1304 - 1315 (2008/02/02)
Starting from a simple chalcone template, structure-activity relationship (SAR) studies led to a series of carboxylated, heteroaryl-substituted chalcone derivatives as novel, potent inhibitors of vascular cell adhesion molecule-1 (VCAM-1) expression. Corr
1,2-BIS-(SUBSTITUTED-PHENYL)-2-PROPEN-1-ONES AND PHARMACEUTICAL COMPOSITIONS THEREOF
-
Page/Page column 79-80, (2010/02/15)
The invention relates to compounds, pharmaceutical compositions and methods of using compounds of the general formula (I), or its pharmaceutically acceptable salt or ester, wherein the substituents are defined in the application.
PROCESS OF MAKING CHALCOME DERIVATIVES
-
Page 72, (2010/02/07)
This invention is a novel methods of manufacturing chalcones that includes reacting a carbon-linked heteroaryl or heterocyclic substituted benzaldehyde with an acetophenone in a solvent or mixture of solvents in the presence of LiOMe. Also provided are new chalcones for the treatment of medical conditions.
