190328-50-8

Basic information

• Product Name: 2-(4-trifluoromethyl-2-aminophenylthio)-benzonitrile
• CAS NO: 190328-50-8
• Molecular Weight: 294.3
• Mol File: 190328-50-8.mol

Chemical Properties

• CAS DataBase Reference: 2-(4-trifluoromethyl-2-aminophenylthio)-benzonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-trifluoromethyl-2-aminophenylthio)-benzonitrile(190328-50-8)
• EPA Substance Registry System: 2-(4-trifluoromethyl-2-aminophenylthio)-benzonitrile(190328-50-8)

Safety Data

• Hazardous Substances Data: 190328-50-8(Hazardous Substances Data)

Upstream product

• 394-47-8 2-fluorobenzonitrile 
• 19406-49-6 2-amino-4-trifluoromethylthiophenol 
• 3159-07-7 dibenzo[b,f][1,4]thiazepin-11-one 
• 4274-38-8 2-amino-4-(trifluoromethyl)benzenethiol hydrochloride 

Relevant articles and documents

Synthesis of 11-Aminodibenzo[b,f][1,4]thiazepines and Fluoro Derivatives

The reaction of halogenobenzonitriles with 2-aminobenzenethiol is a new route, in a "one-pot" or two-step approach, to 11-aminodibenzo[b,f][1,4]thiazepine and fluoro derivatives.

Antiviral dibenzothiazepinone derivatives

Compounds of formula (I) wherein n is 0, 1 or 2; and R1 and R2, which may be the same or different, each represent one or more ring substituent(s) selected from: hydrogen, hydroxy, halogen, cyano, nitro, C1-6 alkyl, C3-6 cycloalkyl or C1-6 alkoxy (where the alkyl or cycloalkyl moiety may be optionally substituted by one or more substituents selected from halogen atoms and hydroxyl groups); --NR4 R5 where R4 and R5, which may be the same or different, each represent hydrogen or C1-6 alkyl; --S(O)m R6, where m is 0, 1, 2 or 3 and R6 represents hydrogen, C1-6 alkyl or C3-6 cycloakyl; --SO2 NR4 R5 where R4 et R5 are each as defined above; phenyl, phenylC1-3 alkoxy or phenylC1-3 alkyl where the phenyl group may be optionally substituted by one or more substituents independently selected from C1-6 alkyl, C1-6 alkoxy, hydroxy, nitro, halogen and amino; and --CO2 H or --COR7 where R7 is C1-6 alkyl or C3-6 cycloalkyl; R3 represents hydrogen or C1-4 alkyl; and esters, salts and other physiologically functional derivatives thereof; show activity as antiviral agents, for example against HIV. Certain of the compounds are novel.

Dibenzothiazepinthione as antiviral agents

Compounds of formula (I) wherein n is 0, 1 or 2; and R1 and R2, which may be the same or different, each represent one or more ring substituent(s) selected from: hydroxy, halogen, cyano, nitro, C1-6 alkyl, C3-6 cycloalkyl or C1-6 alkoxy (where the alkyl or cycloalkyl moiety may be optionally substituted by one or more substituents selected from halogen atoms and hydroxyl groups); --NR4 R5 where R4 and R5 which may be the same or different, each represent hydrogen or C1-6 are each as defined above; phenyl, phenyl C1-3 alkoxy or phenyl C1-3 alkyl where the phenyl group may be optionally substituted by one or more substituents independently selected from C1-6 alkyl, C1-6 alkoxy, hydroxy, nitro, halogen and amino; and --CO2 H or --COR7 where R7 is C1-6 alkyl or C3-6 cycloalkyl; R3 is hydrogen or C1-4 alkyl: and esters, salts and other physiologically functional derivatives thereof, show activity as antiviral agents, for example against HIV. The majority of the compounds are novel.