190381-24-9

Upstream product

• 190381-21-6 3-(2,4-Dimethoxy-6-methoxymethoxy-phenyl)-1-(3,4-dimethoxy-phenyl)-propan-1-ol 
• 190381-20-5 (E)-3-(2,4-Dimethoxy-6-methoxymethoxy-phenyl)-1-(3,4-dimethoxy-phenyl)-propenone 
• 190381-22-7 (E)-1-(3,4-dimethoxyphenyl)-3-(2-methoxy-methyl-4,6-dimethoxy-phenyl)-propene 

Downstream Products

• 58065-34-2 (-)-epicatechin tetramethyl ether 3-O-acetate 
• 132199-49-6 ((-)-catechol)-tetramethyl ether-acetate 

Relevant academic research and scientific papers

Enantioselective synthesis of flavonoids. Part 3. trans- and cis-flavan-3-ol methyl ether acetates

Asymmetric dihydroxylation of a series of polyoxygenated 1,3-diarylpropenes with AD-mix-α or AD-mix-β in the presence of methanesulfonamide and subsequent acid-catalysed cyclization, affords for the first time synthetic access to trans- and cis-flavan-3-ol derivatives, essentially enantiopure and in good yield.

Enantiomers synthesis of the four catechin diastereomer derivatives

Asymmetric dihidroxylalion of (E)-1 -(3,4-dimethoxyphenyl)-3-2-methoxy-methyl-4,6- dimethoxy-phenyl)-propene with AD-mix-α or AD-mix-β in the presence of methanesulfonamide, followed by acid catalysed cyclization, afforded the four catechin diastereomers in high enantiomeric excesses and yields.