190435-73-5Relevant academic research and scientific papers
Synthesis and bioassay of β-(1,4)-D-mannans as potential agents against Alzheimer's disease
Jiang, Ru-Wei,Du, Xiao-Guang,Zhang, Xuan,Wang, Xin,Hu, Ding-Yu,Meng, Tao,Chen, Yue-Lei,Geng, Mei-Yu,Shen, Jing-Kang
, p. 1585 - 1591 (2014/08/05)
Aim: Oligomannurarate 971 derived from a marine plant has shown neuroprotective effects. In this study we synthesized a series of truncated derivatives of the oligosaccharide, and investigated the effect of these derivatives against Aβ peptide toxicity in vitro. Methods: The sulfoxide method was applied to synthesize the derivatives. SH-SY5Y human neuroblastoma cells were treated with A β 1-40 (2 μmol/L), and the cell viability was detected using a CCK8 assay. Results: A series of β-(1,4)-D-mannosyl oligosaccharide, ranging from the disaccharide to the hexasaccharide, were synthesized. Addition of 10 μmol/L β-(1,4)-D-mannobiose 6, β-(1,4)-D-mannotriose 9 or P-(l,4)-D-mannotetraose 12 in SH-SY5Y cells significantly attenuated Aβ1-40-induced toxicity. The efficacies were similar to those caused by 10 μmol/L oligomannurarate 971 or alzhemed. Other oligosaccharides including oligomaltoses and oligocelluloses were less active. Conclusion: Synthetic homogeneous short chain β-(1,4)-D-mannans shows neuroprotective effect against Aβ peptide toxicity similar to that of heterogeneous oligomannurarate 971 and alzhemed.
Synthesis of monosaccharide-fused azetidines
Michaud, Thierry,Chanet-Ray, Josette,Chou, Sithan,Gelas, Jacques
, p. 253 - 269 (2007/10/03)
Primary amines reacted upon 4,6-ditosylates of glucopyranosides to give an azetidine ring fused on C-4 and C-6 of the pyranose ring. On the other hand, the 4,6-ditosylate of benzyl mannopyranoside led to the 4,6-diamino-4,6-dideoxy derivative in a good yield. All the compounds and their precursors were identified by 1H and 13C NMR spectroscopy. Assignments of proton signals were made unambiguously using homodecoupling experiments.
