190442-36-5

Basic information

• Product Name: Carbamic acid, [2-(dimethylamino)-2-oxo-1-phenylethyl]-, phenylmethyl ester, (R)-
• CAS NO: 190442-36-5
• Molecular Formula: C18H20N2O3
• Molecular Weight: 312.368
• Mol File: 190442-36-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Carbamic acid, [2-(dimethylamino)-2-oxo-1-phenylethyl]-, phenylmethyl ester, (R)-(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic acid, [2-(dimethylamino)-2-oxo-1-phenylethyl]-, phenylmethyl ester, (R)-(190442-36-5)
• EPA Substance Registry System: Carbamic acid, [2-(dimethylamino)-2-oxo-1-phenylethyl]-, phenylmethyl ester, (R)-(190442-36-5)

Safety Data

• Hazardous Substances Data: 190442-36-5(Hazardous Substances Data)

Upstream product

• 17609-52-8 Z-D-phenylglycine 
• 506-59-2 N,N-dimethylammonium chloride 

Downstream Products

• 129157-08-0 (R)-2-isopropylamino-N,N-dimethyl-2-phenylethanamide 
• 129157-29-5 (R)-N-(2-phenylglycyl)dimethylamine 

Relevant articles and documents

Stereoselective reactions, 25. Enantioselective deprotonation of prochiral 4-substituted cyclohexanones by chiral chelated lithium amides

Enantioselective deprotonation of prochiral 4-substituted cyclohexanones (4a-d) by chiral chelated lithium amides (8a-k) in the presence of excess trimethylsilyl chloride was realized to give the corresponding chiral silyl enol ethers (6a-d) in up to 89% ee. It is shown that enantioselectivity of the reaction is dependent on the solvent used, but becomes almost independent on the solvent in the presence of HMPA. The sense of asymmetric induction can be correlated to the configuration at the chiral carbon bearing amide nitrogen of the lithium amide.