19048-31-8

Basic information

• Product Name: 2-(4-methoxyphenyl)-1-oxoisoindoline-5-carbonitrile
• Synonyms: 2-(4-methoxyphenyl)-1-oxoisoindoline-5-carbonitrile
• CAS NO: 19048-31-8
• Molecular Weight: 264.283
• Mol File: 19048-31-8.mol

Chemical Properties

• CAS DataBase Reference: 2-(4-methoxyphenyl)-1-oxoisoindoline-5-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-methoxyphenyl)-1-oxoisoindoline-5-carbonitrile(19048-31-8)
• EPA Substance Registry System: 2-(4-methoxyphenyl)-1-oxoisoindoline-5-carbonitrile(19048-31-8)

Safety Data

• Hazardous Substances Data: 19048-31-8(Hazardous Substances Data)

Upstream product

• 104-94-9 4-methoxy-aniline 

Relevant articles and documents

A facile and efficient method for the synthesis of N-substituted isoindolin-1-one derivatives under Pd(OAc)2/HCOOH system

A facile and efficient method for the synthesis of N-substituted isoindolin-1-one derivatives from 2-formylbenzoic acid and amine under Pd(OAc)2/HCOOH system has been described. The whole process is carried out in ligand-free conditions and furnished the desired products by reductive intramolecular cyclization. Furthermore, this procedure is applied successfully for the modification of natural products, such as vindoline and estrone.

Hantzsch ester triggered metal-free cascade approach to isoindolinones

Disclosed herein is an expedient synthesis of biologically important isoindolinone derivatives from reactions of 2-formylbenzoic acids with various amines. This method operates via a deliberately designed catalyst-free tandem reductive amination/cyclization cascade event triggered by a transfer hydrogenation process with easily available Hantzsch ester as the organic hydride source. The ease of operation, mild reaction conditions, facile accessibility of the starting materials, and easy scalability of the current method distinguish it from the other precedent protocols, thus enable it a practical approach to the syntheses of valuable isoindolinone-incorporated drugs.