190520-53-7

Basic information

• Product Name: 2-Thiophenesulfonyl chloride, 3-[2-(4-methylphenyl)ethenyl]-, (E)-
• CAS NO: 190520-53-7
• Molecular Formula: C13H11ClO2S2
• Molecular Weight: 298.814
• Mol File: 190520-53-7.mol

Chemical Properties

• CAS DataBase Reference: 2-Thiophenesulfonyl chloride, 3-[2-(4-methylphenyl)ethenyl]-, (E)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Thiophenesulfonyl chloride, 3-[2-(4-methylphenyl)ethenyl]-, (E)-(190520-53-7)
• EPA Substance Registry System: 2-Thiophenesulfonyl chloride, 3-[2-(4-methylphenyl)ethenyl]-, (E)-(190520-53-7)

Safety Data

• Hazardous Substances Data: 190520-53-7(Hazardous Substances Data)

Upstream product

• 40033-08-7 diethyl (2-bromothiophen-3-yl)methylphosphonate 
• 40032-76-6 2-bromo-3-(bromomethyl)thiophene 
• 190520-47-9 2-Bromo-3-((E)-2-p-tolyl-vinyl)-thiophene 

Relevant articles and documents

Amide bond surrogates: A study in thiophenesulfonamide eased endothelin receptor antagonists

The potential proteolytic instability of the amide bond present in some ET(A) selective thiophenesulfonamide endothelin antagonists exemplified by TBC-10708 led us to investigate the replacement of this moiety with stable amide bond surrogates such as a trans double bond and an ethylene spacer. The effect of these replacements on the binding affinity is described.