19056-76-9

Basic information

• Product Name: 3,7-dimethoxy-2-(3,4,5-trimethoxyphenyl)-4H-chromen-4-one
• Synonyms: 3,7-dimethoxy-2-(3,4,5-trimethoxyphenyl)-4H-chromen-4-one
• CAS NO: 19056-76-9
• Molecular Formula: C₂₀H₂₀O₇
• Molecular Weight: 372.3686
• Mol File: 19056-76-9.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3,7-dimethoxy-2-(3,4,5-trimethoxyphenyl)-4H-chromen-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3,7-dimethoxy-2-(3,4,5-trimethoxyphenyl)-4H-chromen-4-one(19056-76-9)
• EPA Substance Registry System: 3,7-dimethoxy-2-(3,4,5-trimethoxyphenyl)-4H-chromen-4-one(19056-76-9)

Safety Data

• Hazardous Substances Data: 19056-76-9(Hazardous Substances Data)

Upstream product

• 490-31-3 robinetin 
• 77-78-1 dimethyl sulfate 
• 86-81-7 3,4,5-trimethoxy-benzaldehyde 
• 552-41-0 1-(2-hydroxy-4-methoxyphenyl)ethanone 
• 74-88-4 methyl iodide 
• 142955-69-9 1-(2-hydroxy-4-methoxyphenyl)-3-(3,4,5-trimethoxyphenyl)-2-propen-1-one 
• 73489-98-2 3,7-diacetoxy-2-(3,4,5-triacetoxy-phenyl)-chromen-4-one 
• 186581-53-3 diazomethane 

Downstream Products

• 4940-44-7 2'-hydroxy-2,4'-dimethoxyacetophenone 

Relevant articles and documents

Synthesis and effects on cell viability of flavonols and 3-methyl ether derivatives on human leukemia cells

Flavonoids are polyphenolic compounds which display an array of biological activities and are considered potential antitumor agents. Here we evaluated the antiproliferative activity of selected synthetic flavonoids against human leukemia cell lines. We found that 4′-bromoflavonol (flavonol 3) was the most potent. This compound inhibited proliferation in a concentration-dependent manner, induced apoptosis and blocked cell cycle progression at the S phase. Cell death was found to be associated with the cleavage and activation of multiple caspases, the activation of the mitogen-activated protein kinase pathway and the up-regulation of two death receptors (death receptor 4 and death receptor 5) for tumor necrosis factor-related apoptosis-inducing ligand. Moreover, combined treatments using 4′-bromoflavonol and TRAIL led to an increased cytotoxicity compared to single treatments. These results provide a basis for further exploring the potential applications of this combination for the treatment of cancer.