190579-75-0Relevant academic research and scientific papers
Stereoselective synthesis of all stereoisomeric 2-amino3-hydroxy-4-phenylbuntanolides
Gair, Susan,Jackson, Richard F. W.,Brown, Paul A.
, p. 3059 - 3062 (1997)
Diastereoselective methylation of the ketone 5a leads to the anti-derivative 4a; the other diastereoisomer 4b may be obtained by a deprotonation/reprotonation sequence. Each of the methylated products may be reduced stereoselectively in either sense by appropriate choice of reagent, providing a route to all stereoisomers of the title 2-amino-3-hydroxy-4-phenylbutanolides 10a-d.
